Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp

Two new eunicellin-type diterpenoids, cladielloides A (1) and B (2), which were found to possess a 2-hydroxybutyroxy group in their structures, were isolated from an Indonesian octocoral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods. Cladi...

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Autores principales: Chen, Yung-Husan, Tai, Chia-Ying, Hwang, Tsong-Long, Weng, Ching-Feng, Li, Jan-Jung, Fang, Lee-Shing, Wang, Wei-Hsien, Wu, Yang-Chang, Sung, Ping-Jyun
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039462/
https://www.ncbi.nlm.nih.gov/pubmed/21339957
http://dx.doi.org/10.3390/md8122936
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author Chen, Yung-Husan
Tai, Chia-Ying
Hwang, Tsong-Long
Weng, Ching-Feng
Li, Jan-Jung
Fang, Lee-Shing
Wang, Wei-Hsien
Wu, Yang-Chang
Sung, Ping-Jyun
author_facet Chen, Yung-Husan
Tai, Chia-Ying
Hwang, Tsong-Long
Weng, Ching-Feng
Li, Jan-Jung
Fang, Lee-Shing
Wang, Wei-Hsien
Wu, Yang-Chang
Sung, Ping-Jyun
author_sort Chen, Yung-Husan
collection PubMed
description Two new eunicellin-type diterpenoids, cladielloides A (1) and B (2), which were found to possess a 2-hydroxybutyroxy group in their structures, were isolated from an Indonesian octocoral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods. Cladielloide B (2) exhibited moderate cytotoxicity toward CCRF-CEM tumor cells and this compound displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils.
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spelling pubmed-30394622011-02-18 Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp Chen, Yung-Husan Tai, Chia-Ying Hwang, Tsong-Long Weng, Ching-Feng Li, Jan-Jung Fang, Lee-Shing Wang, Wei-Hsien Wu, Yang-Chang Sung, Ping-Jyun Mar Drugs Article Two new eunicellin-type diterpenoids, cladielloides A (1) and B (2), which were found to possess a 2-hydroxybutyroxy group in their structures, were isolated from an Indonesian octocoral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods. Cladielloide B (2) exhibited moderate cytotoxicity toward CCRF-CEM tumor cells and this compound displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils. Molecular Diversity Preservation International 2010-12-06 /pmc/articles/PMC3039462/ /pubmed/21339957 http://dx.doi.org/10.3390/md8122936 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Chen, Yung-Husan
Tai, Chia-Ying
Hwang, Tsong-Long
Weng, Ching-Feng
Li, Jan-Jung
Fang, Lee-Shing
Wang, Wei-Hsien
Wu, Yang-Chang
Sung, Ping-Jyun
Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp
title Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp
title_full Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp
title_fullStr Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp
title_full_unstemmed Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp
title_short Cladielloides A and B: New Eunicellin-Type Diterpenoids from an Indonesian Octocoral Cladiella sp
title_sort cladielloides a and b: new eunicellin-type diterpenoids from an indonesian octocoral cladiella sp
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039462/
https://www.ncbi.nlm.nih.gov/pubmed/21339957
http://dx.doi.org/10.3390/md8122936
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