Levantilides A and B, 20-Membered Macrolides from a Micromonospora Strain Isolated from the Mediterranean Deep Sea Sediment

Two new 20-membered macrolides, levantilide A and B, were isolated from the Micromonospora strain M71-A77. Strain M71-A77 was recovered from an Eastern Mediterranean deep-sea sediment sample and revealed to produce the levantilides under in situ salinity of 38.6‰. The chemical structures of the leva...

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Autores principales: Gärtner, Andrea, Ohlendorf, Birgit, Schulz, Dirk, Zinecker, Heidi, Wiese, Jutta, Imhoff, Johannes F.
Formato: Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039473/
https://www.ncbi.nlm.nih.gov/pubmed/21339949
http://dx.doi.org/10.3390/md9010098
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author Gärtner, Andrea
Ohlendorf, Birgit
Schulz, Dirk
Zinecker, Heidi
Wiese, Jutta
Imhoff, Johannes F.
author_facet Gärtner, Andrea
Ohlendorf, Birgit
Schulz, Dirk
Zinecker, Heidi
Wiese, Jutta
Imhoff, Johannes F.
author_sort Gärtner, Andrea
collection PubMed
description Two new 20-membered macrolides, levantilide A and B, were isolated from the Micromonospora strain M71-A77. Strain M71-A77 was recovered from an Eastern Mediterranean deep-sea sediment sample and revealed to produce the levantilides under in situ salinity of 38.6‰. The chemical structures of the levantilides were elucidated on the basis of different one- and two- dimensional NMR experiments. Levantilide A exhibits a moderate antiproliferative activity against several tumor cell lines.
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spelling pubmed-30394732011-02-18 Levantilides A and B, 20-Membered Macrolides from a Micromonospora Strain Isolated from the Mediterranean Deep Sea Sediment Gärtner, Andrea Ohlendorf, Birgit Schulz, Dirk Zinecker, Heidi Wiese, Jutta Imhoff, Johannes F. Mar Drugs Article Two new 20-membered macrolides, levantilide A and B, were isolated from the Micromonospora strain M71-A77. Strain M71-A77 was recovered from an Eastern Mediterranean deep-sea sediment sample and revealed to produce the levantilides under in situ salinity of 38.6‰. The chemical structures of the levantilides were elucidated on the basis of different one- and two- dimensional NMR experiments. Levantilide A exhibits a moderate antiproliferative activity against several tumor cell lines. Molecular Diversity Preservation International 2011-01-14 /pmc/articles/PMC3039473/ /pubmed/21339949 http://dx.doi.org/10.3390/md9010098 Text en © 2011 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Gärtner, Andrea
Ohlendorf, Birgit
Schulz, Dirk
Zinecker, Heidi
Wiese, Jutta
Imhoff, Johannes F.
Levantilides A and B, 20-Membered Macrolides from a Micromonospora Strain Isolated from the Mediterranean Deep Sea Sediment
title Levantilides A and B, 20-Membered Macrolides from a Micromonospora Strain Isolated from the Mediterranean Deep Sea Sediment
title_full Levantilides A and B, 20-Membered Macrolides from a Micromonospora Strain Isolated from the Mediterranean Deep Sea Sediment
title_fullStr Levantilides A and B, 20-Membered Macrolides from a Micromonospora Strain Isolated from the Mediterranean Deep Sea Sediment
title_full_unstemmed Levantilides A and B, 20-Membered Macrolides from a Micromonospora Strain Isolated from the Mediterranean Deep Sea Sediment
title_short Levantilides A and B, 20-Membered Macrolides from a Micromonospora Strain Isolated from the Mediterranean Deep Sea Sediment
title_sort levantilides a and b, 20-membered macrolides from a micromonospora strain isolated from the mediterranean deep sea sediment
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039473/
https://www.ncbi.nlm.nih.gov/pubmed/21339949
http://dx.doi.org/10.3390/md9010098
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