Cargando…

Partially Randomized, Non-Blinded Trial of DNA and MVA Therapeutic Vaccines Based on Hepatitis B Virus Surface Protein for Chronic HBV Infection

BACKGROUND: Chronic HBV infects 350 million people causing cancer and liver failure. We aimed to assess the safety and efficacy of plasmid DNA (pSG2.HBs) vaccine, followed by recombinant modified vaccinia virus Ankara (MVA.HBs), encoding the surface antigen of HBV as therapy for chronic HBV. A secon...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cavenaugh, James S., Awi, Dorka, Mendy, Maimuna, Hill, Adrian V. S., Whittle, Hilton, McConkey, Samuel J.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039644/ https://www.ncbi.nlm.nih.gov/pubmed/21347224 http://dx.doi.org/10.1371/journal.pone.0014626

Ejemplares similares

Application of real-time PCR to quantify hepatitis B virus DNA in chronic carriers in The Gambia
por: Mendy, Maimuna E, et al.
Publicado: (2006)

Changes in viral load and HBsAg and HBeAg status with age in HBV chronic carriers in The Gambia
por: Mendy, Maimuna E, et al.
Publicado: (2008)

KIR content genotypes associate with carriage of hepatitis B surface antigen, e antigen and HBV viral load in Gambians
por: Yindom, Louis-Marie, et al.
Publicado: (2017)

Long-Term Protection against HBV Chronic Carriage of Gambian Adolescents Vaccinated in Infancy and Immune Response in HBV Booster Trial in Adolescence
por: van der Sande, Marianne A.B., et al.
Publicado: (2007)

Emergence of HBV resistance to lamivudine (3TC) in HIV/HBV co-infected patients in The Gambia, West Africa
por: Stewart, Balint, et al.
Publicado: (2011)

Host Genetic Factors and Vaccine-Induced Immunity to HBV Infection: Haplotype Analysis
por: Ryckman, Kelli K., et al.
Publicado: (2010)

Correction: Host Genetic Factors and Vaccine-Induced Immunity to HBV Infection: Haplotype Analysis
por: Ryckman, Kelli K., et al.
Publicado: (2011)

A Phase Ia Study to Assess the Safety and Immunogenicity of New Malaria Vaccine Candidates ChAd63 CS Administered Alone and with MVA CS
por: de Barra, Eoghan, et al.
Publicado: (2014)

Hepatitis B viral load and risk for liver cirrhosis and hepatocellular carcinoma in The Gambia, West Africa
por: Mendy, M E, et al.
Publicado: (2010)

Aflatoxin Exposure and Viral Hepatitis in the Etiology of Liver Cirrhosis in The Gambia, West Africa
por: Kuniholm, Mark H., et al.
Publicado: (2008)

Observational Study of Vaccine Efficacy 24 Years after the Start of Hepatitis B Vaccination in Two Gambian Villages: No Need for a Booster Dose
por: Mendy, Maimuna, et al.
Publicado: (2013)

Host Genetic Factors and Vaccine-Induced Immunity to Hepatitis B Virus Infection
por: Hennig, Branwen J., et al.
Publicado: (2008)

The association between maternal hepatitis B e antigen status, as a proxy for perinatal transmission, and the risk of hepatitis B e antigenaemia in Gambian children
por: Shimakawa, Yusuke, et al.
Publicado: (2014)

Correction: Host Genetic Factors and Vaccine-Induced Immunity to Hepatitis B Virus Infection
por: Hennig, Branwen J., et al.
Publicado: (2011)

Seroprevalence of hepatitis B and C virus in HIV-1 and HIV-2 infected Gambians
por: Jobarteh, Modou, et al.
Publicado: (2010)

Efficacy and effectiveness of infant vaccination against chronic hepatitis B in the Gambia Hepatitis Intervention Study (1986–90) and in the nationwide immunisation program
por: Peto, Thomas J, et al.
Publicado: (2014)

Influence of adenovirus and MVA vaccines on the breadth and hierarchy of T cell responses
por: Rollier, Christine S., et al.
Publicado: (2016)

Percutaneous Vaccination as an Effective Method of Delivery of MVA and MVA-Vectored Vaccines
por: Meseda, Clement A., et al.
Publicado: (2016)

An audit of knowledge, attitude and sexual practise of HIV positive patients in Beaumont Hospital.
por: McMahon, David, et al.
Publicado: (2015)

A Randomised, Double-Blind, Controlled Vaccine Efficacy Trial of DNA/MVA ME-TRAP Against Malaria Infection in Gambian Adults
por: Moorthy, Vasee S, et al.
Publicado: (2004)

The 90 MVA transformer
Publicado: (1974)

A Brief Measure of Parental Wellbeing for Use in Evaluations of Family-Centred Interventions for Children with Developmental Disabilities
por: McConkey, Roy
Publicado: (2020)

Responding to Autism in Low and Middle Income Countries (Lmic): What to Do and What Not to Do
por: McConkey, Roy
Publicado: (2022)

Seasonal Variation in TP53 R249S-Mutated Serum DNA with Aflatoxin Exposure and Hepatitis B Virus Infection
por: Villar, Stéphanie, et al.
Publicado: (2011)

Immunogenicity of ChAd63 + MVA ME-TRAP in Senegalese adults
por: Mensah, Victorine, et al.
Publicado: (2014)

Molecular and Serological Characterization of Hepatitis B Virus (HBV)-Positive Samples with Very Low or Undetectable Levels of HBV Surface Antigen
por: Kuhns, Mary C., et al.
Publicado: (2021)

Hepatitis B Surface Antigen Concentrations in Patients with HIV/HBV Co-Infection
por: Jaroszewicz, Jerzy, et al.
Publicado: (2012)

Correlation Between Hepatitis B Surface Antigen Titers and HBV DNA Levels
por: Alghamdi, Amal, et al.
Publicado: (2013)

Administración financiera por objetivos
por: McConkey, Dale D.
Publicado: (1982)

12 guiding premises of pediatric cochlear implant habilitation
por: McConkey Robbins, Amy
Publicado: (2018)

Mac-2 binding protein glycosylation isomer (M2BPGi) to evaluate liver fibrosis and cancer in HBV-infected patients in West Africa
por: Vincent, Jeanne Perpétue, et al.
Publicado: (2022)

An MVA Approach to Missing $E_T$
por: Herwig, Theodor Christian
Publicado: (2013)

Ciliopathy in PCS (MVA) syndrome
por: Miyamoto, Tatsuo, et al.
Publicado: (2015)

Safety and Immunogenicity of the Candidate Tuberculosis Vaccine MVA85A in West Africa
por: Brookes, Roger H., et al.
Publicado: (2008)

Structural motif screening reveals a novel, conserved carbohydrate-binding surface in the pathogenesis-related protein PR-5d
por: Doxey, Andrew C, et al.
Publicado: (2010)

Hospital inpatient care utilization among patients with tuberculosis, Republic of Ireland, 2015–2018
por: O’Connell, James, et al.
Publicado: (2020)

Systematic review of latent tuberculosis infection research to inform programmatic management in Ireland
por: O’Connell, James, et al.
Publicado: (2021)

A blind spot? Confronting the stigma of hepatitis B virus (HBV) infection - A systematic review
por: Mokaya, Jolynne, et al.
Publicado: (2018)

Mechanism of pyocyanin abolishment caused by mvaT mvaU double knockout in Pseudomonas aeruginosa PAO1
por: Dong, Limin, et al.
Publicado: (2019)

THE RELATION OF VITAMIN C DEFICIENCY TO INTESTINAL TUBERCULOSIS IN THE GUINEA PIG
por: McConkey, Mack, et al.
Publicado: (1933)

Cannot write session to /tmp/vufind_sessions/sess_cpfhmfb7njujcfq3mkjo60pe7j