HP1-Mediated Formation of Alternative Lengthening of Telomeres-Associated PML Bodies Requires HIRA but Not ASF1a

Approximately 10% of cancers use recombination-mediated Alternative Lengthening of Telomeres (ALT) instead of telomerase to prevent telomere shortening. A characteristic of cells that utilize ALT is the presence of ALT-associated PML nuclear bodies (APBs) containing (TTAGGG)n DNA, telomere binding p...

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Detalles Bibliográficos
Autores principales: Jiang, Wei-Qin, Nguyen, Akira, Cao, Ying, Chang, Andy C.-M., Reddel, Roger R.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039646/
https://www.ncbi.nlm.nih.gov/pubmed/21347226
http://dx.doi.org/10.1371/journal.pone.0017036

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