Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors

Attenuated poxviruses are safe and capable of expressing foreign antigens. Poxviruses are applied in veterinary vaccination and explored as candidate vaccines for humans. However, poxviruses express multiple genes encoding proteins that interfere with components of the innate and adaptive immune res...

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Detalles Bibliográficos
Autores principales: Quakkelaar, Esther D., Redeker, Anke, Haddad, Elias K., Harari, Alexandre, McCaughey, Stella Mayo, Duhen, Thomas, Filali-Mouhim, Abdelali, Goulet, Jean-Philippe, Loof, Nikki M., Ossendorp, Ferry, Perdiguero, Beatriz, Heinen, Paul, Gomez, Carmen E., Kibler, Karen V., Koelle, David M., Sékaly, Rafick P., Sallusto, Federica, Lanzavecchia, Antonio, Pantaleo, Giuseppe, Esteban, Mariano, Tartaglia, Jim, Jacobs, Bertram L., Melief, Cornelis J. M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039654/
https://www.ncbi.nlm.nih.gov/pubmed/21347234
http://dx.doi.org/10.1371/journal.pone.0016819

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