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Identification of Small Molecule Lead Compounds for Visceral Leishmaniasis Using a Novel Ex Vivo Splenic Explant Model System

BACKGROUND: New drugs are needed to treat visceral leishmaniasis (VL) because the current therapies are toxic, expensive, and parasite resistance may weaken drug efficacy. We established a novel ex vivo splenic explant culture system from hamsters infected with luciferase-transfected Leishmania dono...

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Detalles Bibliográficos
Autores principales:	Osorio, Yaneth, Travi, Bruno L., Renslo, Adam R., Peniche, Alex G., Melby, Peter C.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039689/ https://www.ncbi.nlm.nih.gov/pubmed/21358812 http://dx.doi.org/10.1371/journal.pntd.0000962

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