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Risk of second cancers after the diagnosis of Merkel cell carcinoma in Scandinavia
BACKGROUND: Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumour of the skin that has been associated with a new tumour virus, the MCC polyomavirus. METHODS: To investigate whether MCC may have a shared aetiology with other cancers, we investigated the risk of second cancers after the...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039797/ https://www.ncbi.nlm.nih.gov/pubmed/21081931 http://dx.doi.org/10.1038/sj.bjc.6605989 |
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author | Bzhalava, D Bray, F Storm, H Dillner, J |
author_facet | Bzhalava, D Bray, F Storm, H Dillner, J |
author_sort | Bzhalava, D |
collection | PubMed |
description | BACKGROUND: Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumour of the skin that has been associated with a new tumour virus, the MCC polyomavirus. METHODS: To investigate whether MCC may have a shared aetiology with other cancers, we investigated the risk of second cancers after the diagnosis of MCC using the national cancer registries in Denmark, Norway and Sweden. RESULTS: The overall cancer incidence was increased among patients diagnosed with MCC compared with the general population in these countries (79 secondary cancers total, Standardized Incidence Ratio (SIR) 1.38 (95% confidence interval (CI): 1.10–1.72); 49 secondary cancer in females, SIR 1.7 (95% CI: 1.29–2.25); 30 secondary cancers in males and SIR 1.05 (95% CI: 0.73-1.5)). There were significantly increased incidence ratios for non-melanoma skin cancers (34 secondary cancers, SIR 8.35 (95% CI: 5.97–11.68)), melanoma of skin (6 secondary cancers, SIR 4.29 (95% CI: 1.93–9.56)) and laryngeal cancer (2 secondary cancers, SIR 9.51 (95% CI: 2.38–38)). The SIRs for these three cancer sites were also elevated on restricting the follow-up to cancers occurring at least one year after MCC diagnosis. CONCLUSIONS: Patients diagnosed with MCC are at increased risk of a second cancer, particularly, other skin cancers. Conceivable explanations include the impact of increased surveillance of the skin and shared causative factors, for example, ultraviolet light exposure or MCC polyomavirus infection. |
format | Text |
id | pubmed-3039797 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-30397972012-01-04 Risk of second cancers after the diagnosis of Merkel cell carcinoma in Scandinavia Bzhalava, D Bray, F Storm, H Dillner, J Br J Cancer Short Communication BACKGROUND: Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumour of the skin that has been associated with a new tumour virus, the MCC polyomavirus. METHODS: To investigate whether MCC may have a shared aetiology with other cancers, we investigated the risk of second cancers after the diagnosis of MCC using the national cancer registries in Denmark, Norway and Sweden. RESULTS: The overall cancer incidence was increased among patients diagnosed with MCC compared with the general population in these countries (79 secondary cancers total, Standardized Incidence Ratio (SIR) 1.38 (95% confidence interval (CI): 1.10–1.72); 49 secondary cancer in females, SIR 1.7 (95% CI: 1.29–2.25); 30 secondary cancers in males and SIR 1.05 (95% CI: 0.73-1.5)). There were significantly increased incidence ratios for non-melanoma skin cancers (34 secondary cancers, SIR 8.35 (95% CI: 5.97–11.68)), melanoma of skin (6 secondary cancers, SIR 4.29 (95% CI: 1.93–9.56)) and laryngeal cancer (2 secondary cancers, SIR 9.51 (95% CI: 2.38–38)). The SIRs for these three cancer sites were also elevated on restricting the follow-up to cancers occurring at least one year after MCC diagnosis. CONCLUSIONS: Patients diagnosed with MCC are at increased risk of a second cancer, particularly, other skin cancers. Conceivable explanations include the impact of increased surveillance of the skin and shared causative factors, for example, ultraviolet light exposure or MCC polyomavirus infection. Nature Publishing Group 2011-01-04 2010-11-16 /pmc/articles/PMC3039797/ /pubmed/21081931 http://dx.doi.org/10.1038/sj.bjc.6605989 Text en Copyright © 2011 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Short Communication Bzhalava, D Bray, F Storm, H Dillner, J Risk of second cancers after the diagnosis of Merkel cell carcinoma in Scandinavia |
title | Risk of second cancers after the diagnosis of Merkel cell carcinoma in Scandinavia |
title_full | Risk of second cancers after the diagnosis of Merkel cell carcinoma in Scandinavia |
title_fullStr | Risk of second cancers after the diagnosis of Merkel cell carcinoma in Scandinavia |
title_full_unstemmed | Risk of second cancers after the diagnosis of Merkel cell carcinoma in Scandinavia |
title_short | Risk of second cancers after the diagnosis of Merkel cell carcinoma in Scandinavia |
title_sort | risk of second cancers after the diagnosis of merkel cell carcinoma in scandinavia |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039797/ https://www.ncbi.nlm.nih.gov/pubmed/21081931 http://dx.doi.org/10.1038/sj.bjc.6605989 |
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