The role of FKBP5 in cancer aetiology and chemoresistance

FK506 binding protein 51 (FKBP51, also called FKBP5) belongs to a family of immunophilins, FK506 binding proteins (FKBPs). Members of this family are targets for drugs such as rapamycin and cyclosporine. Although FKBP5 shares characteristics with other FKBPs, it also has unique features, especially...

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Detalles Bibliográficos
Autores principales: Li, L, Lou, Z, Wang, L
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039800/
https://www.ncbi.nlm.nih.gov/pubmed/21119664
http://dx.doi.org/10.1038/sj.bjc.6606014
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author Li, L
Lou, Z
Wang, L
author_facet Li, L
Lou, Z
Wang, L
author_sort Li, L
collection PubMed
description FK506 binding protein 51 (FKBP51, also called FKBP5) belongs to a family of immunophilins, FK506 binding proteins (FKBPs). Members of this family are targets for drugs such as rapamycin and cyclosporine. Although FKBP5 shares characteristics with other FKBPs, it also has unique features, especially its role in the regulation of multiple signalling pathways and in tumourigenesis and chemoresistance. In this review, we will focus on the recently discovered role of FKBP5 in cancer aetiology and response to antineoplastic therapy.
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spelling pubmed-30398002012-01-04 The role of FKBP5 in cancer aetiology and chemoresistance Li, L Lou, Z Wang, L Br J Cancer Minireview FK506 binding protein 51 (FKBP51, also called FKBP5) belongs to a family of immunophilins, FK506 binding proteins (FKBPs). Members of this family are targets for drugs such as rapamycin and cyclosporine. Although FKBP5 shares characteristics with other FKBPs, it also has unique features, especially its role in the regulation of multiple signalling pathways and in tumourigenesis and chemoresistance. In this review, we will focus on the recently discovered role of FKBP5 in cancer aetiology and response to antineoplastic therapy. Nature Publishing Group 2011-01-04 2010-11-30 /pmc/articles/PMC3039800/ /pubmed/21119664 http://dx.doi.org/10.1038/sj.bjc.6606014 Text en Copyright © 2011 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Li, L
Lou, Z
Wang, L
The role of FKBP5 in cancer aetiology and chemoresistance
title The role of FKBP5 in cancer aetiology and chemoresistance
title_full The role of FKBP5 in cancer aetiology and chemoresistance
title_fullStr The role of FKBP5 in cancer aetiology and chemoresistance
title_full_unstemmed The role of FKBP5 in cancer aetiology and chemoresistance
title_short The role of FKBP5 in cancer aetiology and chemoresistance
title_sort role of fkbp5 in cancer aetiology and chemoresistance
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039800/
https://www.ncbi.nlm.nih.gov/pubmed/21119664
http://dx.doi.org/10.1038/sj.bjc.6606014
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