Antiproliferative and proapoptotic activity of GUT-70 mediated through potent inhibition of Hsp90 in mantle cell lymphoma

BACKGROUND: Mantle cell lymphoma (MCL) is an aggressive B-cell lymphoma with poor prognosis, requiring novel anticancer strategies. METHODS: Mantle cell lymphoma cell lines with known p53 status were treated with GUT-70, a tricyclic coumarin derived from Calophyllum brasiliense, and the biological a...

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Detalles Bibliográficos
Autores principales: Jin, L, Tabe, Y, Kimura, S, Zhou, Y, Kuroda, J, Asou, H, Inaba, T, Konopleva, M, Andreeff, M, Miida, T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039813/
https://www.ncbi.nlm.nih.gov/pubmed/21139584
http://dx.doi.org/10.1038/sj.bjc.6606007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039813/
https://www.ncbi.nlm.nih.gov/pubmed/21139584
http://dx.doi.org/10.1038/sj.bjc.6606007

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