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Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development

The mechanisms controlling mammalian organ size have long been a source of fascination for biologists. These controls are needed to both ensure the integrity of the body plan and to restrict inappropriate proliferation that could lead to cancer. Regulation of liver size is of particular interest ina...

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Autores principales: Avruch, J, Zhou, D, Fitamant, J, Bardeesy, N
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039822/
https://www.ncbi.nlm.nih.gov/pubmed/21102585
http://dx.doi.org/10.1038/sj.bjc.6606011
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author Avruch, J
Zhou, D
Fitamant, J
Bardeesy, N
author_facet Avruch, J
Zhou, D
Fitamant, J
Bardeesy, N
author_sort Avruch, J
collection PubMed
description The mechanisms controlling mammalian organ size have long been a source of fascination for biologists. These controls are needed to both ensure the integrity of the body plan and to restrict inappropriate proliferation that could lead to cancer. Regulation of liver size is of particular interest inasmuch as this organ maintains the capacity for regeneration throughout life, and is able to regain precisely its original mass after partial surgical resection. Recent studies using genetically engineered mouse strains have shed new light on this problem; the Hippo signalling pathway, first elucidated as a regulator of organ size in Drosophila, has been identified as dominant determinant of liver growth. Defects in this pathway in mouse liver lead to sustained liver overgrowth and the eventual development of both major types of liver cancer, hepatocellular carcinoma and cholangiocarcinoma. In this review, we discuss the role of Hippo signalling in liver biology and the contribution of this pathway to liver cancer in humans.
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spelling pubmed-30398222012-01-04 Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development Avruch, J Zhou, D Fitamant, J Bardeesy, N Br J Cancer Minireview The mechanisms controlling mammalian organ size have long been a source of fascination for biologists. These controls are needed to both ensure the integrity of the body plan and to restrict inappropriate proliferation that could lead to cancer. Regulation of liver size is of particular interest inasmuch as this organ maintains the capacity for regeneration throughout life, and is able to regain precisely its original mass after partial surgical resection. Recent studies using genetically engineered mouse strains have shed new light on this problem; the Hippo signalling pathway, first elucidated as a regulator of organ size in Drosophila, has been identified as dominant determinant of liver growth. Defects in this pathway in mouse liver lead to sustained liver overgrowth and the eventual development of both major types of liver cancer, hepatocellular carcinoma and cholangiocarcinoma. In this review, we discuss the role of Hippo signalling in liver biology and the contribution of this pathway to liver cancer in humans. Nature Publishing Group 2011-01-04 2010-11-23 /pmc/articles/PMC3039822/ /pubmed/21102585 http://dx.doi.org/10.1038/sj.bjc.6606011 Text en Copyright © 2011 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Avruch, J
Zhou, D
Fitamant, J
Bardeesy, N
Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development
title Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development
title_full Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development
title_fullStr Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development
title_full_unstemmed Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development
title_short Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development
title_sort mst1/2 signalling to yap: gatekeeper for liver size and tumour development
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039822/
https://www.ncbi.nlm.nih.gov/pubmed/21102585
http://dx.doi.org/10.1038/sj.bjc.6606011
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