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PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice

Stimulatory and inhibitory co-receptors play fundamental roles in the regulation of the immune system. We describe a new mouse model of spontaneous autoimmune disease. Activation-induced cytidine deaminase–linked autoimmunity (aida) mice harbor a loss-of-function mutation in the gene encoding lympho...

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Detalles Bibliográficos
Autores principales:	Okazaki, Taku, Okazaki, Il-mi, Wang, Jian, Sugiura, Daisuke, Nakaki, Fumio, Yoshida, Taku, Kato, Yu, Fagarasan, Sidonia, Muramatsu, Masamichi, Eto, Tomoo, Hioki, Kyoji, Honjo, Tasuku
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039848/ https://www.ncbi.nlm.nih.gov/pubmed/21300912 http://dx.doi.org/10.1084/jem.20100466

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