The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells

Graft-versus-host disease (GVHD) is a major complication of allogeneic bone marrow transplantation (BMT), and damage to the gastrointestinal (GI) tract plays a critical role in amplifying systemic disease. Intestinal stem cells (ISCs) play a pivotal role not only in physiological tissue renewal but...

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Detalles Bibliográficos
Autores principales: Takashima, Shuichiro, Kadowaki, Masanori, Aoyama, Kazutoshi, Koyama, Motoko, Oshima, Takeshi, Tomizuka, Kazuma, Akashi, Koichi, Teshima, Takanori
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039850/
https://www.ncbi.nlm.nih.gov/pubmed/21282378
http://dx.doi.org/10.1084/jem.20101559

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