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Early diagnosis of systemic lupus erythmatosus using ANN models of dsDNA binding antibody sequence data

In this paper a new method based on artificial neural networks (ANN), is introduced for identifying pathogenic antibodies in Systemic Lupus Erythmatosus (SLE). dsDNA binding antibodies have been implicated in the pathogenesis of this autoimmune disease. In order to identify these dsDNA binding antib...

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Autores principales: Bahari, Mohamad Hasan, Mahmoudi, Mahmoud, Azemi, Asad, Mirsalehi, Mir Mojtaba, Khademi, Morteza
Formato: Texto
Lenguaje:English
Publicado: Biomedical Informatics 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039990/
https://www.ncbi.nlm.nih.gov/pubmed/21346864
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author Bahari, Mohamad Hasan
Mahmoudi, Mahmoud
Azemi, Asad
Mirsalehi, Mir Mojtaba
Khademi, Morteza
author_facet Bahari, Mohamad Hasan
Mahmoudi, Mahmoud
Azemi, Asad
Mirsalehi, Mir Mojtaba
Khademi, Morteza
author_sort Bahari, Mohamad Hasan
collection PubMed
description In this paper a new method based on artificial neural networks (ANN), is introduced for identifying pathogenic antibodies in Systemic Lupus Erythmatosus (SLE). dsDNA binding antibodies have been implicated in the pathogenesis of this autoimmune disease. In order to identify these dsDNA binding antibodies, the protein sequences of 42 dsDNA binding and 608 non-dsDNA binding antibodies were extracted from Kabat database and encoded using a physicochemical property of their amino acids namely Hydrophilicity. Encoded antibodies were used as the training patterns of a general regression neural network (GRNN). Simulation results show that the accuracy of proposed method in recognizing dsDNA binding antibodies is 83.2%. We have also investigated the roles of the light and heavy chains of anti-dsDNA antibodies in binding to DNA. Simulation results concur with the published experimental findings that in binding to DNA, the heavy chain of anti-dsDNA is more important than their light chain.
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spelling pubmed-30399902011-02-23 Early diagnosis of systemic lupus erythmatosus using ANN models of dsDNA binding antibody sequence data Bahari, Mohamad Hasan Mahmoudi, Mahmoud Azemi, Asad Mirsalehi, Mir Mojtaba Khademi, Morteza Bioinformation Hypothesis In this paper a new method based on artificial neural networks (ANN), is introduced for identifying pathogenic antibodies in Systemic Lupus Erythmatosus (SLE). dsDNA binding antibodies have been implicated in the pathogenesis of this autoimmune disease. In order to identify these dsDNA binding antibodies, the protein sequences of 42 dsDNA binding and 608 non-dsDNA binding antibodies were extracted from Kabat database and encoded using a physicochemical property of their amino acids namely Hydrophilicity. Encoded antibodies were used as the training patterns of a general regression neural network (GRNN). Simulation results show that the accuracy of proposed method in recognizing dsDNA binding antibodies is 83.2%. We have also investigated the roles of the light and heavy chains of anti-dsDNA antibodies in binding to DNA. Simulation results concur with the published experimental findings that in binding to DNA, the heavy chain of anti-dsDNA is more important than their light chain. Biomedical Informatics 2010-07-06 /pmc/articles/PMC3039990/ /pubmed/21346864 Text en © 2010 Biomedical Informatics This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Bahari, Mohamad Hasan
Mahmoudi, Mahmoud
Azemi, Asad
Mirsalehi, Mir Mojtaba
Khademi, Morteza
Early diagnosis of systemic lupus erythmatosus using ANN models of dsDNA binding antibody sequence data
title Early diagnosis of systemic lupus erythmatosus using ANN models of dsDNA binding antibody sequence data
title_full Early diagnosis of systemic lupus erythmatosus using ANN models of dsDNA binding antibody sequence data
title_fullStr Early diagnosis of systemic lupus erythmatosus using ANN models of dsDNA binding antibody sequence data
title_full_unstemmed Early diagnosis of systemic lupus erythmatosus using ANN models of dsDNA binding antibody sequence data
title_short Early diagnosis of systemic lupus erythmatosus using ANN models of dsDNA binding antibody sequence data
title_sort early diagnosis of systemic lupus erythmatosus using ann models of dsdna binding antibody sequence data
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039990/
https://www.ncbi.nlm.nih.gov/pubmed/21346864
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