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Comparative analysis of organophosphate degrading enzymes from diverse species

Different types of organophosphorous compounds constitute most potent pesticides. These chemicals attack the nervous system of living organisms causing death. Different organisms produce enzymes to degrade these chemicals. These enzymes are present in simple microorganisms from archaea, bacteria to...

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Autores principales: Salman, Amna, Fard, Atefeh Taherian, Nasir, Arshan, Bokhari, Habib
Formato: Texto
Lenguaje:English
Publicado: Biomedical Informatics 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039992/
https://www.ncbi.nlm.nih.gov/pubmed/21346866
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author Salman, Amna
Fard, Atefeh Taherian
Nasir, Arshan
Bokhari, Habib
author_facet Salman, Amna
Fard, Atefeh Taherian
Nasir, Arshan
Bokhari, Habib
author_sort Salman, Amna
collection PubMed
description Different types of organophosphorous compounds constitute most potent pesticides. These chemicals attack the nervous system of living organisms causing death. Different organisms produce enzymes to degrade these chemicals. These enzymes are present in simple microorganisms from archaea, bacteria to complex eukaryotes like humans. A comparison of representative eight shortlisted enzymes involved in the degradation and inactivation of organophosphates from a wide range of organisms was performed to infer the basis of their common functionality. There is little sequence homology in these enzymes which results in divergent tertiary structures. The only feature that these enzymes seem to share is their amino acid composition. However, structural analysis has shown no significant similarities among this functionally similar group of organophosphate degrading enzymes.
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spelling pubmed-30399922011-02-23 Comparative analysis of organophosphate degrading enzymes from diverse species Salman, Amna Fard, Atefeh Taherian Nasir, Arshan Bokhari, Habib Bioinformation Hypothesis Different types of organophosphorous compounds constitute most potent pesticides. These chemicals attack the nervous system of living organisms causing death. Different organisms produce enzymes to degrade these chemicals. These enzymes are present in simple microorganisms from archaea, bacteria to complex eukaryotes like humans. A comparison of representative eight shortlisted enzymes involved in the degradation and inactivation of organophosphates from a wide range of organisms was performed to infer the basis of their common functionality. There is little sequence homology in these enzymes which results in divergent tertiary structures. The only feature that these enzymes seem to share is their amino acid composition. However, structural analysis has shown no significant similarities among this functionally similar group of organophosphate degrading enzymes. Biomedical Informatics 2010-07-06 /pmc/articles/PMC3039992/ /pubmed/21346866 Text en © 2010 Biomedical Informatics This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Salman, Amna
Fard, Atefeh Taherian
Nasir, Arshan
Bokhari, Habib
Comparative analysis of organophosphate degrading enzymes from diverse species
title Comparative analysis of organophosphate degrading enzymes from diverse species
title_full Comparative analysis of organophosphate degrading enzymes from diverse species
title_fullStr Comparative analysis of organophosphate degrading enzymes from diverse species
title_full_unstemmed Comparative analysis of organophosphate degrading enzymes from diverse species
title_short Comparative analysis of organophosphate degrading enzymes from diverse species
title_sort comparative analysis of organophosphate degrading enzymes from diverse species
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3039992/
https://www.ncbi.nlm.nih.gov/pubmed/21346866
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