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Discriminating antigen and non-antigen using proteome dissimilarity II: viral and fungal antigens

Immunogenicity arises via many synergistic mechanisms, yet the overall dissimilarity of pathogenic proteins versus the host proteome has been proposed as a key arbiter. We have previously explored this concept in relation to Bacterial antigens; here we extend our analysis to antigens of viral and fu...

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Autores principales: Ramakrishnan, Kamna, Flower, Darren R
Formato: Texto
Lenguaje:English
Publicado: Biomedical Informatics 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040003/
https://www.ncbi.nlm.nih.gov/pubmed/21346877
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author Ramakrishnan, Kamna
Flower, Darren R
author_facet Ramakrishnan, Kamna
Flower, Darren R
author_sort Ramakrishnan, Kamna
collection PubMed
description Immunogenicity arises via many synergistic mechanisms, yet the overall dissimilarity of pathogenic proteins versus the host proteome has been proposed as a key arbiter. We have previously explored this concept in relation to Bacterial antigens; here we extend our analysis to antigens of viral and fungal origin. Sets of known viral and fungal antigenic and non-antigenic protein sequences were compared to human and mouse proteomes. Both antigenic and non-antigenic sequences lacked human or mouse homologues. Observed distributions were compared using the non-parametric Mann-Whitney test. The statistical null hypothesis was accepted, indicating that antigen and non-antigens did not differ significantly. Likewise, we could not determine a threshold able meaningfully to separate non-antigen from antigen. We conclude that viral and fungal antigens cannot be predicted from pathogen genomes based solely on their dissimilarity to mammalian genomes.
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spelling pubmed-30400032011-02-23 Discriminating antigen and non-antigen using proteome dissimilarity II: viral and fungal antigens Ramakrishnan, Kamna Flower, Darren R Bioinformation Hypothesis Immunogenicity arises via many synergistic mechanisms, yet the overall dissimilarity of pathogenic proteins versus the host proteome has been proposed as a key arbiter. We have previously explored this concept in relation to Bacterial antigens; here we extend our analysis to antigens of viral and fungal origin. Sets of known viral and fungal antigenic and non-antigenic protein sequences were compared to human and mouse proteomes. Both antigenic and non-antigenic sequences lacked human or mouse homologues. Observed distributions were compared using the non-parametric Mann-Whitney test. The statistical null hypothesis was accepted, indicating that antigen and non-antigens did not differ significantly. Likewise, we could not determine a threshold able meaningfully to separate non-antigen from antigen. We conclude that viral and fungal antigens cannot be predicted from pathogen genomes based solely on their dissimilarity to mammalian genomes. Biomedical Informatics 2010-06-24 /pmc/articles/PMC3040003/ /pubmed/21346877 Text en © 2010 Biomedical Informatics This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Ramakrishnan, Kamna
Flower, Darren R
Discriminating antigen and non-antigen using proteome dissimilarity II: viral and fungal antigens
title Discriminating antigen and non-antigen using proteome dissimilarity II: viral and fungal antigens
title_full Discriminating antigen and non-antigen using proteome dissimilarity II: viral and fungal antigens
title_fullStr Discriminating antigen and non-antigen using proteome dissimilarity II: viral and fungal antigens
title_full_unstemmed Discriminating antigen and non-antigen using proteome dissimilarity II: viral and fungal antigens
title_short Discriminating antigen and non-antigen using proteome dissimilarity II: viral and fungal antigens
title_sort discriminating antigen and non-antigen using proteome dissimilarity ii: viral and fungal antigens
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040003/
https://www.ncbi.nlm.nih.gov/pubmed/21346877
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