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A Tripartite Synapse Model in Drosophila

Tripartite (three-part) synapses are defined by physical and functional interactions of glia with pre- and post-synaptic elements. Although tripartite synapses are thought to be of widespread importance in neurological health and disease, we are only beginning to develop an understanding of glial co...

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Detalles Bibliográficos
Autores principales: Danjo, Rie, Kawasaki, Fumiko, Ordway, Richard W.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040228/
https://www.ncbi.nlm.nih.gov/pubmed/21359186
http://dx.doi.org/10.1371/journal.pone.0017131
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author Danjo, Rie
Kawasaki, Fumiko
Ordway, Richard W.
author_facet Danjo, Rie
Kawasaki, Fumiko
Ordway, Richard W.
author_sort Danjo, Rie
collection PubMed
description Tripartite (three-part) synapses are defined by physical and functional interactions of glia with pre- and post-synaptic elements. Although tripartite synapses are thought to be of widespread importance in neurological health and disease, we are only beginning to develop an understanding of glial contributions to synaptic function. In contrast to studies of neuronal mechanisms, a significant limitation has been the lack of an invertebrate genetic model system in which conserved mechanisms of tripartite synapse function may be examined through large-scale application of forward genetics and genome-wide genetic tools. Here we report a Drosophila tripartite synapse model which exhibits morphological and functional properties similar to those of mammalian synapses, including glial regulation of extracellular glutamate, synaptically-induced glial calcium transients and glial coupling of synapses with tracheal structures mediating gas exchange. In combination with classical and cell-type specific genetic approaches in Drosophila, this model is expected to provide new insights into the molecular and cellular mechanisms of tripartite synapse function.
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spelling pubmed-30402282011-02-25 A Tripartite Synapse Model in Drosophila Danjo, Rie Kawasaki, Fumiko Ordway, Richard W. PLoS One Research Article Tripartite (three-part) synapses are defined by physical and functional interactions of glia with pre- and post-synaptic elements. Although tripartite synapses are thought to be of widespread importance in neurological health and disease, we are only beginning to develop an understanding of glial contributions to synaptic function. In contrast to studies of neuronal mechanisms, a significant limitation has been the lack of an invertebrate genetic model system in which conserved mechanisms of tripartite synapse function may be examined through large-scale application of forward genetics and genome-wide genetic tools. Here we report a Drosophila tripartite synapse model which exhibits morphological and functional properties similar to those of mammalian synapses, including glial regulation of extracellular glutamate, synaptically-induced glial calcium transients and glial coupling of synapses with tracheal structures mediating gas exchange. In combination with classical and cell-type specific genetic approaches in Drosophila, this model is expected to provide new insights into the molecular and cellular mechanisms of tripartite synapse function. Public Library of Science 2011-02-16 /pmc/articles/PMC3040228/ /pubmed/21359186 http://dx.doi.org/10.1371/journal.pone.0017131 Text en Danjo et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Danjo, Rie
Kawasaki, Fumiko
Ordway, Richard W.
A Tripartite Synapse Model in Drosophila
title A Tripartite Synapse Model in Drosophila
title_full A Tripartite Synapse Model in Drosophila
title_fullStr A Tripartite Synapse Model in Drosophila
title_full_unstemmed A Tripartite Synapse Model in Drosophila
title_short A Tripartite Synapse Model in Drosophila
title_sort tripartite synapse model in drosophila
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040228/
https://www.ncbi.nlm.nih.gov/pubmed/21359186
http://dx.doi.org/10.1371/journal.pone.0017131
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