Fate mapping of interleukin 17-producing T cells in inflammatory responses

We describe a reporter mouse strain designed to fate-map cells that have activated IL-17A. Here we show that T(H)17 cells show distinct plasticity in different inflammatory settings. Chronic inflammatory conditions in EAE caused a switch to alternative cytokines in T(H)17 cells, whereas acute cutane...

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Autores principales: Hirota, K., Duarte, J.H., Veldhoen, M., Hornsby, E., Li, Y., Cua, D.J., Ahlfors, H., Wilhelm, C., Tolaini, M., Menzel, U., Garefalaki, A., Potocnik, A.J., Stockinger, B
Formato: Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040235/
https://www.ncbi.nlm.nih.gov/pubmed/21278737
http://dx.doi.org/10.1038/ni.1993
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author Hirota, K.
Duarte, J.H.
Veldhoen, M.
Hornsby, E.
Li, Y.
Cua, D.J.
Ahlfors, H.
Wilhelm, C.
Tolaini, M.
Menzel, U.
Garefalaki, A.
Potocnik, A.J.
Stockinger, B
author_facet Hirota, K.
Duarte, J.H.
Veldhoen, M.
Hornsby, E.
Li, Y.
Cua, D.J.
Ahlfors, H.
Wilhelm, C.
Tolaini, M.
Menzel, U.
Garefalaki, A.
Potocnik, A.J.
Stockinger, B
author_sort Hirota, K.
collection PubMed
description We describe a reporter mouse strain designed to fate-map cells that have activated IL-17A. Here we show that T(H)17 cells show distinct plasticity in different inflammatory settings. Chronic inflammatory conditions in EAE caused a switch to alternative cytokines in T(H)17 cells, whereas acute cutaneous infection with Candida albicans, did not result in deviation of T(H)17 to alternative cytokine production, although IL-17A production was shut off in the course of the infection. During development of EAE, IFN-γ and other pro-inflammatory cytokines in the spinal cord were produced almost exclusively by ‘ex-T(H)17’ cells whose conversion was driven by IL-23. Thus, this model allows relating the actual functional fate of effector T cells to T(H)17 developmental origin irrespective of IL-17 expression.
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spelling pubmed-30402352011-09-01 Fate mapping of interleukin 17-producing T cells in inflammatory responses Hirota, K. Duarte, J.H. Veldhoen, M. Hornsby, E. Li, Y. Cua, D.J. Ahlfors, H. Wilhelm, C. Tolaini, M. Menzel, U. Garefalaki, A. Potocnik, A.J. Stockinger, B Nat Immunol Article We describe a reporter mouse strain designed to fate-map cells that have activated IL-17A. Here we show that T(H)17 cells show distinct plasticity in different inflammatory settings. Chronic inflammatory conditions in EAE caused a switch to alternative cytokines in T(H)17 cells, whereas acute cutaneous infection with Candida albicans, did not result in deviation of T(H)17 to alternative cytokine production, although IL-17A production was shut off in the course of the infection. During development of EAE, IFN-γ and other pro-inflammatory cytokines in the spinal cord were produced almost exclusively by ‘ex-T(H)17’ cells whose conversion was driven by IL-23. Thus, this model allows relating the actual functional fate of effector T cells to T(H)17 developmental origin irrespective of IL-17 expression. 2011-01-30 2011-03 /pmc/articles/PMC3040235/ /pubmed/21278737 http://dx.doi.org/10.1038/ni.1993 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Hirota, K.
Duarte, J.H.
Veldhoen, M.
Hornsby, E.
Li, Y.
Cua, D.J.
Ahlfors, H.
Wilhelm, C.
Tolaini, M.
Menzel, U.
Garefalaki, A.
Potocnik, A.J.
Stockinger, B
Fate mapping of interleukin 17-producing T cells in inflammatory responses
title Fate mapping of interleukin 17-producing T cells in inflammatory responses
title_full Fate mapping of interleukin 17-producing T cells in inflammatory responses
title_fullStr Fate mapping of interleukin 17-producing T cells in inflammatory responses
title_full_unstemmed Fate mapping of interleukin 17-producing T cells in inflammatory responses
title_short Fate mapping of interleukin 17-producing T cells in inflammatory responses
title_sort fate mapping of interleukin 17-producing t cells in inflammatory responses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040235/
https://www.ncbi.nlm.nih.gov/pubmed/21278737
http://dx.doi.org/10.1038/ni.1993
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