Iodine Deficiency in Northern Paris Area: Impact on Fetal Thyroid Mensuration

INTRODUCTION: Iodine is essential for normal fetal and neonatal development. We studied the prevalence and impact on fetal thyroid development of iodine deficiency in pregnant women in the northern part of the Paris conurbation. MATERIALS AND METHODS: 110 patients underwent several determinations of...

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Detalles Bibliográficos
Autores principales: Luton, Dominique, Alberti, Corinne, Vuillard, Edith, Ducarme, Guillaume, Oury, Jean François, Guibourdenche, Jean
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040245/
https://www.ncbi.nlm.nih.gov/pubmed/21359193
http://dx.doi.org/10.1371/journal.pone.0014707
Descripción
Sumario:INTRODUCTION: Iodine is essential for normal fetal and neonatal development. We studied the prevalence and impact on fetal thyroid development of iodine deficiency in pregnant women in the northern part of the Paris conurbation. MATERIALS AND METHODS: 110 patients underwent several determinations of urinary iodine excretion (UIE) and of serum FT4, FT3, and TSH. Fetal thyroid gland size was assessed using ultrasonography. RESULTS: We found evidence of widespread iodine deficiency (mean UIE, 49.8 µg/L [standard deviation, 2.11]). Iodine deficiency did not correlate significantly with maternal thyroid parameters but showed a significant negative correlation with fetal thyroid gland size (rho = 0.25, P = 0.02). CONCLUSION: Iodine deficiency during pregnancy is still a problem in our geographical area and affects the fetal thyroid gland. Clinical Trials.gov NCT00162539

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