Iodine Deficiency in Northern Paris Area: Impact on Fetal Thyroid Mensuration

INTRODUCTION: Iodine is essential for normal fetal and neonatal development. We studied the prevalence and impact on fetal thyroid development of iodine deficiency in pregnant women in the northern part of the Paris conurbation. MATERIALS AND METHODS: 110 patients underwent several determinations of...

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Autores principales: Luton, Dominique, Alberti, Corinne, Vuillard, Edith, Ducarme, Guillaume, Oury, Jean François, Guibourdenche, Jean
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040245/
https://www.ncbi.nlm.nih.gov/pubmed/21359193
http://dx.doi.org/10.1371/journal.pone.0014707
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author Luton, Dominique
Alberti, Corinne
Vuillard, Edith
Ducarme, Guillaume
Oury, Jean François
Guibourdenche, Jean
author_facet Luton, Dominique
Alberti, Corinne
Vuillard, Edith
Ducarme, Guillaume
Oury, Jean François
Guibourdenche, Jean
author_sort Luton, Dominique
collection PubMed
description INTRODUCTION: Iodine is essential for normal fetal and neonatal development. We studied the prevalence and impact on fetal thyroid development of iodine deficiency in pregnant women in the northern part of the Paris conurbation. MATERIALS AND METHODS: 110 patients underwent several determinations of urinary iodine excretion (UIE) and of serum FT4, FT3, and TSH. Fetal thyroid gland size was assessed using ultrasonography. RESULTS: We found evidence of widespread iodine deficiency (mean UIE, 49.8 µg/L [standard deviation, 2.11]). Iodine deficiency did not correlate significantly with maternal thyroid parameters but showed a significant negative correlation with fetal thyroid gland size (rho = 0.25, P = 0.02). CONCLUSION: Iodine deficiency during pregnancy is still a problem in our geographical area and affects the fetal thyroid gland. Clinical Trials.gov NCT00162539
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spelling pubmed-30402452011-02-25 Iodine Deficiency in Northern Paris Area: Impact on Fetal Thyroid Mensuration Luton, Dominique Alberti, Corinne Vuillard, Edith Ducarme, Guillaume Oury, Jean François Guibourdenche, Jean PLoS One Research Article INTRODUCTION: Iodine is essential for normal fetal and neonatal development. We studied the prevalence and impact on fetal thyroid development of iodine deficiency in pregnant women in the northern part of the Paris conurbation. MATERIALS AND METHODS: 110 patients underwent several determinations of urinary iodine excretion (UIE) and of serum FT4, FT3, and TSH. Fetal thyroid gland size was assessed using ultrasonography. RESULTS: We found evidence of widespread iodine deficiency (mean UIE, 49.8 µg/L [standard deviation, 2.11]). Iodine deficiency did not correlate significantly with maternal thyroid parameters but showed a significant negative correlation with fetal thyroid gland size (rho = 0.25, P = 0.02). CONCLUSION: Iodine deficiency during pregnancy is still a problem in our geographical area and affects the fetal thyroid gland. Clinical Trials.gov NCT00162539 Public Library of Science 2011-02-16 /pmc/articles/PMC3040245/ /pubmed/21359193 http://dx.doi.org/10.1371/journal.pone.0014707 Text en Luton et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Luton, Dominique
Alberti, Corinne
Vuillard, Edith
Ducarme, Guillaume
Oury, Jean François
Guibourdenche, Jean
Iodine Deficiency in Northern Paris Area: Impact on Fetal Thyroid Mensuration
title Iodine Deficiency in Northern Paris Area: Impact on Fetal Thyroid Mensuration
title_full Iodine Deficiency in Northern Paris Area: Impact on Fetal Thyroid Mensuration
title_fullStr Iodine Deficiency in Northern Paris Area: Impact on Fetal Thyroid Mensuration
title_full_unstemmed Iodine Deficiency in Northern Paris Area: Impact on Fetal Thyroid Mensuration
title_short Iodine Deficiency in Northern Paris Area: Impact on Fetal Thyroid Mensuration
title_sort iodine deficiency in northern paris area: impact on fetal thyroid mensuration
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040245/
https://www.ncbi.nlm.nih.gov/pubmed/21359193
http://dx.doi.org/10.1371/journal.pone.0014707
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