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Prediction of miRNA targets, affected proteins and their homologs in Glycine max

microRNAs are small noncoding RNA gene products about 20-24nt long that are processed by Dicer from precursors with a characteristic hairpin secondary structure. As miRNAs affect the morphology of plants and animals by the posttranscriptional regulation of genes involved in critical developmental ev...

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Autores principales: Katara, Pramod, Gautam, Budhayash, Kuntal, Himani, Sharma, Vinay
Formato: Texto
Lenguaje:English
Publicado: Biomedical Informatics 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040477/
https://www.ncbi.nlm.nih.gov/pubmed/21364779
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author Katara, Pramod
Gautam, Budhayash
Kuntal, Himani
Sharma, Vinay
author_facet Katara, Pramod
Gautam, Budhayash
Kuntal, Himani
Sharma, Vinay
author_sort Katara, Pramod
collection PubMed
description microRNAs are small noncoding RNA gene products about 20-24nt long that are processed by Dicer from precursors with a characteristic hairpin secondary structure. As miRNAs affect the morphology of plants and animals by the posttranscriptional regulation of genes involved in critical developmental events, it has been proposed that precise regulation of miRNAs activity during various stages of growth and in specific cell types is of central importance for normal plant development. In our work we focus on the plant miRNAs and predict the miRNA targets, affected proteins by miRNA and miRNA homologs of Glycine max. Our analyses were based on sequence complementarities between miRNAs and mRNAs. As a result, we predicted 573 targets for 44 mature miRNAs sequences among 69 mature miRNAs sequences were published in database. Study of affected proteins revealed that for very less number of miRNAs, protein products are known and they mostly involved in diverse physiological process like as element of photosynthesis system. Homology analyses for miRNAs suggested that 22 miRNAs of Glycine max show 418 miRNA homologs for different plant species
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spelling pubmed-30404772011-03-01 Prediction of miRNA targets, affected proteins and their homologs in Glycine max Katara, Pramod Gautam, Budhayash Kuntal, Himani Sharma, Vinay Bioinformation Hypothesis microRNAs are small noncoding RNA gene products about 20-24nt long that are processed by Dicer from precursors with a characteristic hairpin secondary structure. As miRNAs affect the morphology of plants and animals by the posttranscriptional regulation of genes involved in critical developmental events, it has been proposed that precise regulation of miRNAs activity during various stages of growth and in specific cell types is of central importance for normal plant development. In our work we focus on the plant miRNAs and predict the miRNA targets, affected proteins by miRNA and miRNA homologs of Glycine max. Our analyses were based on sequence complementarities between miRNAs and mRNAs. As a result, we predicted 573 targets for 44 mature miRNAs sequences among 69 mature miRNAs sequences were published in database. Study of affected proteins revealed that for very less number of miRNAs, protein products are known and they mostly involved in diverse physiological process like as element of photosynthesis system. Homology analyses for miRNAs suggested that 22 miRNAs of Glycine max show 418 miRNA homologs for different plant species Biomedical Informatics 2010-09-20 /pmc/articles/PMC3040477/ /pubmed/21364779 Text en © 2010 Biomedical Informatics This is an open-access article, which permits unrestricted use, distribution, and reproduction in any medium, for non-commercial purposes, provided the original author and source are credited.
spellingShingle Hypothesis
Katara, Pramod
Gautam, Budhayash
Kuntal, Himani
Sharma, Vinay
Prediction of miRNA targets, affected proteins and their homologs in Glycine max
title Prediction of miRNA targets, affected proteins and their homologs in Glycine max
title_full Prediction of miRNA targets, affected proteins and their homologs in Glycine max
title_fullStr Prediction of miRNA targets, affected proteins and their homologs in Glycine max
title_full_unstemmed Prediction of miRNA targets, affected proteins and their homologs in Glycine max
title_short Prediction of miRNA targets, affected proteins and their homologs in Glycine max
title_sort prediction of mirna targets, affected proteins and their homologs in glycine max
topic Hypothesis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040477/
https://www.ncbi.nlm.nih.gov/pubmed/21364779
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