Characterisation of the proteome, diseases and evolution of the human postsynaptic density

The postsynaptic density from human neocortex (hPSD) was isolated and 1461 proteins identified. hPSD mutations cause 133 neurological and psychiatric diseases and show enrichment in cognitive, affective and motor phenotypes underpinned by sets of genes. Strong protein sequence conservation within ma...

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Detalles Bibliográficos
Autores principales: Bayés, Àlex, van de Lagemaat, Louie N., Collins, Mark O., Croning, Mike D.R., Whittle, Ian R., Choudhary, Jyoti S., Grant, Seth G.N.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040565/
https://www.ncbi.nlm.nih.gov/pubmed/21170055
http://dx.doi.org/10.1038/nn.2719
Descripción
Sumario:The postsynaptic density from human neocortex (hPSD) was isolated and 1461 proteins identified. hPSD mutations cause 133 neurological and psychiatric diseases and show enrichment in cognitive, affective and motor phenotypes underpinned by sets of genes. Strong protein sequence conservation within mammalian lineages, particularly in hub proteins, indicates conserved function and organisation in primate and rodent models. The hPSD is a key structure for nervous system disease and behaviour.

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