Characterisation of the proteome, diseases and evolution of the human postsynaptic density

The postsynaptic density from human neocortex (hPSD) was isolated and 1461 proteins identified. hPSD mutations cause 133 neurological and psychiatric diseases and show enrichment in cognitive, affective and motor phenotypes underpinned by sets of genes. Strong protein sequence conservation within ma...

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Autores principales: Bayés, Àlex, van de Lagemaat, Louie N., Collins, Mark O., Croning, Mike D.R., Whittle, Ian R., Choudhary, Jyoti S., Grant, Seth G.N.
Formato: Texto
Lenguaje:English
Publicado: 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040565/
https://www.ncbi.nlm.nih.gov/pubmed/21170055
http://dx.doi.org/10.1038/nn.2719
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author Bayés, Àlex
van de Lagemaat, Louie N.
Collins, Mark O.
Croning, Mike D.R.
Whittle, Ian R.
Choudhary, Jyoti S.
Grant, Seth G.N.
author_facet Bayés, Àlex
van de Lagemaat, Louie N.
Collins, Mark O.
Croning, Mike D.R.
Whittle, Ian R.
Choudhary, Jyoti S.
Grant, Seth G.N.
author_sort Bayés, Àlex
collection PubMed
description The postsynaptic density from human neocortex (hPSD) was isolated and 1461 proteins identified. hPSD mutations cause 133 neurological and psychiatric diseases and show enrichment in cognitive, affective and motor phenotypes underpinned by sets of genes. Strong protein sequence conservation within mammalian lineages, particularly in hub proteins, indicates conserved function and organisation in primate and rodent models. The hPSD is a key structure for nervous system disease and behaviour.
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spelling pubmed-30405652011-07-01 Characterisation of the proteome, diseases and evolution of the human postsynaptic density Bayés, Àlex van de Lagemaat, Louie N. Collins, Mark O. Croning, Mike D.R. Whittle, Ian R. Choudhary, Jyoti S. Grant, Seth G.N. Nat Neurosci Article The postsynaptic density from human neocortex (hPSD) was isolated and 1461 proteins identified. hPSD mutations cause 133 neurological and psychiatric diseases and show enrichment in cognitive, affective and motor phenotypes underpinned by sets of genes. Strong protein sequence conservation within mammalian lineages, particularly in hub proteins, indicates conserved function and organisation in primate and rodent models. The hPSD is a key structure for nervous system disease and behaviour. 2010-12-19 2011-01 /pmc/articles/PMC3040565/ /pubmed/21170055 http://dx.doi.org/10.1038/nn.2719 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Bayés, Àlex
van de Lagemaat, Louie N.
Collins, Mark O.
Croning, Mike D.R.
Whittle, Ian R.
Choudhary, Jyoti S.
Grant, Seth G.N.
Characterisation of the proteome, diseases and evolution of the human postsynaptic density
title Characterisation of the proteome, diseases and evolution of the human postsynaptic density
title_full Characterisation of the proteome, diseases and evolution of the human postsynaptic density
title_fullStr Characterisation of the proteome, diseases and evolution of the human postsynaptic density
title_full_unstemmed Characterisation of the proteome, diseases and evolution of the human postsynaptic density
title_short Characterisation of the proteome, diseases and evolution of the human postsynaptic density
title_sort characterisation of the proteome, diseases and evolution of the human postsynaptic density
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040565/
https://www.ncbi.nlm.nih.gov/pubmed/21170055
http://dx.doi.org/10.1038/nn.2719
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