Prevalence of Epistasis in the Evolution of Influenza A Surface Proteins

The surface proteins of human influenza A viruses experience positive selection to escape both human immunity and, more recently, antiviral drug treatments. In bacteria and viruses, immune-escape and drug-resistant phenotypes often appear through a combination of several mutations that have epistati...

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Detalles Bibliográficos
Autores principales: Kryazhimskiy, Sergey, Dushoff, Jonathan, Bazykin, Georgii A., Plotkin, Joshua B.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040651/
https://www.ncbi.nlm.nih.gov/pubmed/21390205
http://dx.doi.org/10.1371/journal.pgen.1001301

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040651/
https://www.ncbi.nlm.nih.gov/pubmed/21390205
http://dx.doi.org/10.1371/journal.pgen.1001301

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