Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune Response to Virulent Legionella pneumophila

The intracellular bacterial pathogen Legionella pneumophila causes an inflammatory pneumonia called Legionnaires' Disease. For virulence, L. pneumophila requires a Dot/Icm type IV secretion system that translocates bacterial effectors to the host cytosol. L. pneumophila lacking the Dot/Icm syst...

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Detalles Bibliográficos
Autores principales: Fontana, Mary F., Banga, Simran, Barry, Kevin C., Shen, Xihui, Tan, Yunhao, Luo, Zhao-Qing, Vance, Russell E.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040669/
https://www.ncbi.nlm.nih.gov/pubmed/21390206
http://dx.doi.org/10.1371/journal.ppat.1001289

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