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DC-SIGN Mediated Sphingomyelinase-Activation and Ceramide Generation Is Essential for Enhancement of Viral Uptake in Dendritic Cells

As pattern recognition receptor on dendritic cells (DCs), DC-SIGN binds carbohydrate structures on its pathogen ligands and essentially determines host pathogen interactions because it both skews T cell responses and enhances pathogen uptake for cis infection and/or T cell trans-infection. How these...

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Detalles Bibliográficos
Autores principales: Avota, Elita, Gulbins, Erich, Schneider-Schaulies, Sibylle
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040670/
https://www.ncbi.nlm.nih.gov/pubmed/21379338
http://dx.doi.org/10.1371/journal.ppat.1001290