Genital Tract Sequestration of SIV following Acute Infection

We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between...

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Detalles Bibliográficos
Autores principales: Whitney, James B., Hraber, Peter T., Luedemann, Corinne, Giorgi, Elena E., Daniels, Marcus G., Bhattacharya, Tanmoy, Rao, Srinivas S., Mascola, John R., Nabel, Gary J., Korber, Bette T., Letvin, Norman L.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040679/
https://www.ncbi.nlm.nih.gov/pubmed/21379569
http://dx.doi.org/10.1371/journal.ppat.1001293
Descripción
Sumario:We characterized the evolution of simian immunodeficiency virus (SIV) in the male genital tract by examining blood- and semen-associated virus from experimentally and sham vaccinated rhesus monkeys during primary infection. At the time of peak virus replication, SIV sequences were intermixed between the blood and semen supporting a scenario of high-level virus “spillover” into the male genital tract. However, at the time of virus set point, compartmentalization was apparent in 4 of 7 evaluated monkeys, likely as a consequence of restricted virus gene flow between anatomic compartments after the resolution of primary viremia. These findings suggest that SIV replication in the male genital tract evolves to compartmentalization after peak viremia resolves.

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