pH-Induced In Situ Gel for Periodontal Anesthesia

A pH mediated in situ gelling system was developed using prilocaine hydrochloride for periodontal anesthesia using combination of chitosan and hydroxypropylmethylcellulose. The gel so developed can be used as anaesthetic in lengthy dental surgery. The gel was evaluated for many parameters like gelat...

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Detalles Bibliográficos
Autores principales: Gupta, H., Singh, R. M., Singh, G. N., Kaushik, D., Sharma, A.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Short Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040872/
https://www.ncbi.nlm.nih.gov/pubmed/21369439
http://dx.doi.org/10.4103/0250-474X.49120
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author Gupta, H.
Singh, R. M.
Singh, G. N.
Kaushik, D.
Sharma, A.
author_facet Gupta, H.
Singh, R. M.
Singh, G. N.
Kaushik, D.
Sharma, A.
author_sort Gupta, H.
collection PubMed
description A pH mediated in situ gelling system was developed using prilocaine hydrochloride for periodontal anesthesia using combination of chitosan and hydroxypropylmethylcellulose. The gel so developed can be used as anaesthetic in lengthy dental surgery. The gel was evaluated for many parameters like gelation pH, viscosity, physicochemical properties, in vitro release, sterility and stability. Gel with chitosan (0.25% w/v) and hydroxypropylmethylcellulose (0.25% w/v) was found to have good gelation near pH 7.4 (pH of mucous) with prolonged action.
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spelling pubmed-30408722011-03-02 pH-Induced In Situ Gel for Periodontal Anesthesia Gupta, H. Singh, R. M. Singh, G. N. Kaushik, D. Sharma, A. Indian J Pharm Sci Short Communications A pH mediated in situ gelling system was developed using prilocaine hydrochloride for periodontal anesthesia using combination of chitosan and hydroxypropylmethylcellulose. The gel so developed can be used as anaesthetic in lengthy dental surgery. The gel was evaluated for many parameters like gelation pH, viscosity, physicochemical properties, in vitro release, sterility and stability. Gel with chitosan (0.25% w/v) and hydroxypropylmethylcellulose (0.25% w/v) was found to have good gelation near pH 7.4 (pH of mucous) with prolonged action. Medknow Publications 2008 /pmc/articles/PMC3040872/ /pubmed/21369439 http://dx.doi.org/10.4103/0250-474X.49120 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communications
Gupta, H.
Singh, R. M.
Singh, G. N.
Kaushik, D.
Sharma, A.
pH-Induced In Situ Gel for Periodontal Anesthesia
title pH-Induced In Situ Gel for Periodontal Anesthesia
title_full pH-Induced In Situ Gel for Periodontal Anesthesia
title_fullStr pH-Induced In Situ Gel for Periodontal Anesthesia
title_full_unstemmed pH-Induced In Situ Gel for Periodontal Anesthesia
title_short pH-Induced In Situ Gel for Periodontal Anesthesia
title_sort ph-induced in situ gel for periodontal anesthesia
topic Short Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040872/
https://www.ncbi.nlm.nih.gov/pubmed/21369439
http://dx.doi.org/10.4103/0250-474X.49120
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AT sharmaa phinducedinsitugelforperiodontalanesthesia

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