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Antioxidant and Antiinflammatory Activity of Vitex negundo

Reactive oxygen species are implicated in various inflammatory disorders. Vitex negundo is mentioned in Ayurveda as useful in treating arthritic disorders. The present work was undertaken to evaluate the antioxidant potential and anti-inflammatory activity of the plant. The total methanol extract of...

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Detalles Bibliográficos
Autores principales: Kulkarni, R. R., Virkar, A. D., D'mello, Priscilla
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040892/
https://www.ncbi.nlm.nih.gov/pubmed/21369459
http://dx.doi.org/10.4103/0250-474X.49140
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author Kulkarni, R. R.
Virkar, A. D.
D'mello, Priscilla
author_facet Kulkarni, R. R.
Virkar, A. D.
D'mello, Priscilla
author_sort Kulkarni, R. R.
collection PubMed
description Reactive oxygen species are implicated in various inflammatory disorders. Vitex negundo is mentioned in Ayurveda as useful in treating arthritic disorders. The present work was undertaken to evaluate the antioxidant potential and anti-inflammatory activity of the plant. The total methanol extract of the plant was standardized in terms of total polyphenols. The standardized extract in a dose of 100 mg/kg caused a comparable reduction in edema with that of diclofenac sodium (25 mg/kg) when evaluated for antiinflammatory activity by carrageenan-induced rat paw edema method. The extract also exhibited a strong free radical scavenging activity by 1,1-diphenyl-2-picrylhydrazyl method and caused a significant reduction in the formation of thiobarbituric acid reacting substances when evaluated for its lipid peroxidation inhibitory activity. The results strongly suggest that radical quenching may be one of the mechanisms responsible for its antiinflammatory activity.
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spelling pubmed-30408922011-03-02 Antioxidant and Antiinflammatory Activity of Vitex negundo Kulkarni, R. R. Virkar, A. D. D'mello, Priscilla Indian J Pharm Sci Short Communication Reactive oxygen species are implicated in various inflammatory disorders. Vitex negundo is mentioned in Ayurveda as useful in treating arthritic disorders. The present work was undertaken to evaluate the antioxidant potential and anti-inflammatory activity of the plant. The total methanol extract of the plant was standardized in terms of total polyphenols. The standardized extract in a dose of 100 mg/kg caused a comparable reduction in edema with that of diclofenac sodium (25 mg/kg) when evaluated for antiinflammatory activity by carrageenan-induced rat paw edema method. The extract also exhibited a strong free radical scavenging activity by 1,1-diphenyl-2-picrylhydrazyl method and caused a significant reduction in the formation of thiobarbituric acid reacting substances when evaluated for its lipid peroxidation inhibitory activity. The results strongly suggest that radical quenching may be one of the mechanisms responsible for its antiinflammatory activity. Medknow Publications 2008 /pmc/articles/PMC3040892/ /pubmed/21369459 http://dx.doi.org/10.4103/0250-474X.49140 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Kulkarni, R. R.
Virkar, A. D.
D'mello, Priscilla
Antioxidant and Antiinflammatory Activity of Vitex negundo
title Antioxidant and Antiinflammatory Activity of Vitex negundo
title_full Antioxidant and Antiinflammatory Activity of Vitex negundo
title_fullStr Antioxidant and Antiinflammatory Activity of Vitex negundo
title_full_unstemmed Antioxidant and Antiinflammatory Activity of Vitex negundo
title_short Antioxidant and Antiinflammatory Activity of Vitex negundo
title_sort antioxidant and antiinflammatory activity of vitex negundo
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040892/
https://www.ncbi.nlm.nih.gov/pubmed/21369459
http://dx.doi.org/10.4103/0250-474X.49140
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