Antidiabetic Activity of Clerodendron phlomoidis Leaf Extract in Alloxan-Induced Diabetic Rats

Ethanol extract of leaves of Clerodendron phlomoidis L. subjected to preliminary qualitative phytochemical investigations showed the presence of alkaloids, phytosterols, glycosides, saponins, phenolic compounds, proteins and flavonoids. The extract was screened for hypoglycemic activity in alloxan-i...

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Autores principales: Dhanabal, S. P., Mohan Marugaraja, M. K., Suresh, B.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2008
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040893/
https://www.ncbi.nlm.nih.gov/pubmed/21369460
http://dx.doi.org/10.4103/0250-474X.49141
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author Dhanabal, S. P.
Mohan Marugaraja, M. K.
Suresh, B.
author_facet Dhanabal, S. P.
Mohan Marugaraja, M. K.
Suresh, B.
author_sort Dhanabal, S. P.
collection PubMed
description Ethanol extract of leaves of Clerodendron phlomoidis L. subjected to preliminary qualitative phytochemical investigations showed the presence of alkaloids, phytosterols, glycosides, saponins, phenolic compounds, proteins and flavonoids. The extract was screened for hypoglycemic activity in alloxan-induced diabetic rats (120 mg/kg, i.p.) at two dose levels, viz., 100 and 200 mg/kg. The ethanol extract at 200 mg/kg dose level exhibited significant (p<0.05) hypoglycemic activity and also correction of altered biochemical parameters viz., cholesterol and triglycerides (p<0.05).
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spelling pubmed-30408932011-03-02 Antidiabetic Activity of Clerodendron phlomoidis Leaf Extract in Alloxan-Induced Diabetic Rats Dhanabal, S. P. Mohan Marugaraja, M. K. Suresh, B. Indian J Pharm Sci Short Communication Ethanol extract of leaves of Clerodendron phlomoidis L. subjected to preliminary qualitative phytochemical investigations showed the presence of alkaloids, phytosterols, glycosides, saponins, phenolic compounds, proteins and flavonoids. The extract was screened for hypoglycemic activity in alloxan-induced diabetic rats (120 mg/kg, i.p.) at two dose levels, viz., 100 and 200 mg/kg. The ethanol extract at 200 mg/kg dose level exhibited significant (p<0.05) hypoglycemic activity and also correction of altered biochemical parameters viz., cholesterol and triglycerides (p<0.05). Medknow Publications 2008 /pmc/articles/PMC3040893/ /pubmed/21369460 http://dx.doi.org/10.4103/0250-474X.49141 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Dhanabal, S. P.
Mohan Marugaraja, M. K.
Suresh, B.
Antidiabetic Activity of Clerodendron phlomoidis Leaf Extract in Alloxan-Induced Diabetic Rats
title Antidiabetic Activity of Clerodendron phlomoidis Leaf Extract in Alloxan-Induced Diabetic Rats
title_full Antidiabetic Activity of Clerodendron phlomoidis Leaf Extract in Alloxan-Induced Diabetic Rats
title_fullStr Antidiabetic Activity of Clerodendron phlomoidis Leaf Extract in Alloxan-Induced Diabetic Rats
title_full_unstemmed Antidiabetic Activity of Clerodendron phlomoidis Leaf Extract in Alloxan-Induced Diabetic Rats
title_short Antidiabetic Activity of Clerodendron phlomoidis Leaf Extract in Alloxan-Induced Diabetic Rats
title_sort antidiabetic activity of clerodendron phlomoidis leaf extract in alloxan-induced diabetic rats
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040893/
https://www.ncbi.nlm.nih.gov/pubmed/21369460
http://dx.doi.org/10.4103/0250-474X.49141
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