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Impaired Endothelial Function in Preadolescent Children With Type 1 Diabetes
OBJECTIVE: We evaluated the prevalence of endothelial dysfunction as measured by flow-mediated dilatation (FMD) of the brachial artery and carotid intima-media thickness (c-IMT) in relationship to vascular inflammatory biomarkers in preadolescent children with type 1 diabetes. RESEARCH DESIGN AND ME...
Autores principales: | , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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American Diabetes Association
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041207/ https://www.ncbi.nlm.nih.gov/pubmed/21289230 http://dx.doi.org/10.2337/dc10-2134 |
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author | Babar, Ghufran S. Zidan, Hanaa Widlansky, Michael E. Das, Emon Hoffmann, Raymond G. Daoud, Marwan Alemzadeh, Ramin |
author_facet | Babar, Ghufran S. Zidan, Hanaa Widlansky, Michael E. Das, Emon Hoffmann, Raymond G. Daoud, Marwan Alemzadeh, Ramin |
author_sort | Babar, Ghufran S. |
collection | PubMed |
description | OBJECTIVE: We evaluated the prevalence of endothelial dysfunction as measured by flow-mediated dilatation (FMD) of the brachial artery and carotid intima-media thickness (c-IMT) in relationship to vascular inflammatory biomarkers in preadolescent children with type 1 diabetes. RESEARCH DESIGN AND METHODS: We studied 21 type 1 diabetic children (aged 8.3 ± 0.3 years with diabetes duration of 4.3 ± 0.4 years) and 15 group-matched healthy siblings (aged 7.6 ± 0.3 years). Fasting plasma glucose (FPG), lipid profile, HbA(1c), high-sensitivity C-reactive protein (hs-CRP), fibrinogen, homocysteine, and erythrocyte (red blood cell [RBC]) folate were evaluated in all subjects. Each subject underwent c-IMT and brachial artery FMD percentage (FMD%) measurements using high-resolution vascular ultrasound. RESULTS: Type 1 diabetic children had higher FPG (173.4 ± 7.9 mg/dL vs. 81.40 ± 1.7 mg/dL; P < 0.0001), HbA(1c) (8.0 ± 0.2% vs. 5.0 ± 0.1%; P < 0.0001), and hs-CRP (1.8 ± 0.3 vs. 0.70 ± 0.2; P = 0.017) than control children without significant differences in BMI, homocysteine, and fibrinogen levels; RBC folate content; and c-IMT between the groups. Children with type 1 diabetes had lower FMD% than control children (7.1 ± 0.8% vs. 9.8 ± 1.1%; P = 0.04), whereas c-IMT did not differ between groups. CONCLUSIONS: Preadolescent children with type 1 diabetes and mean diabetes duration of 4 years displayed evidence of low-intensity vascular inflammation and attenuated FMD measurements. These data suggest that endothelial dysfunction and systemic inflammation, known harbingers of future cardiovascular risk, are present even in preadolescent children. |
format | Text |
id | pubmed-3041207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-30412072012-03-01 Impaired Endothelial Function in Preadolescent Children With Type 1 Diabetes Babar, Ghufran S. Zidan, Hanaa Widlansky, Michael E. Das, Emon Hoffmann, Raymond G. Daoud, Marwan Alemzadeh, Ramin Diabetes Care Original Research OBJECTIVE: We evaluated the prevalence of endothelial dysfunction as measured by flow-mediated dilatation (FMD) of the brachial artery and carotid intima-media thickness (c-IMT) in relationship to vascular inflammatory biomarkers in preadolescent children with type 1 diabetes. RESEARCH DESIGN AND METHODS: We studied 21 type 1 diabetic children (aged 8.3 ± 0.3 years with diabetes duration of 4.3 ± 0.4 years) and 15 group-matched healthy siblings (aged 7.6 ± 0.3 years). Fasting plasma glucose (FPG), lipid profile, HbA(1c), high-sensitivity C-reactive protein (hs-CRP), fibrinogen, homocysteine, and erythrocyte (red blood cell [RBC]) folate were evaluated in all subjects. Each subject underwent c-IMT and brachial artery FMD percentage (FMD%) measurements using high-resolution vascular ultrasound. RESULTS: Type 1 diabetic children had higher FPG (173.4 ± 7.9 mg/dL vs. 81.40 ± 1.7 mg/dL; P < 0.0001), HbA(1c) (8.0 ± 0.2% vs. 5.0 ± 0.1%; P < 0.0001), and hs-CRP (1.8 ± 0.3 vs. 0.70 ± 0.2; P = 0.017) than control children without significant differences in BMI, homocysteine, and fibrinogen levels; RBC folate content; and c-IMT between the groups. Children with type 1 diabetes had lower FMD% than control children (7.1 ± 0.8% vs. 9.8 ± 1.1%; P = 0.04), whereas c-IMT did not differ between groups. CONCLUSIONS: Preadolescent children with type 1 diabetes and mean diabetes duration of 4 years displayed evidence of low-intensity vascular inflammation and attenuated FMD measurements. These data suggest that endothelial dysfunction and systemic inflammation, known harbingers of future cardiovascular risk, are present even in preadolescent children. American Diabetes Association 2011-03 2011-02-17 /pmc/articles/PMC3041207/ /pubmed/21289230 http://dx.doi.org/10.2337/dc10-2134 Text en © 2011 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Original Research Babar, Ghufran S. Zidan, Hanaa Widlansky, Michael E. Das, Emon Hoffmann, Raymond G. Daoud, Marwan Alemzadeh, Ramin Impaired Endothelial Function in Preadolescent Children With Type 1 Diabetes |
title | Impaired Endothelial Function in Preadolescent Children With Type 1 Diabetes |
title_full | Impaired Endothelial Function in Preadolescent Children With Type 1 Diabetes |
title_fullStr | Impaired Endothelial Function in Preadolescent Children With Type 1 Diabetes |
title_full_unstemmed | Impaired Endothelial Function in Preadolescent Children With Type 1 Diabetes |
title_short | Impaired Endothelial Function in Preadolescent Children With Type 1 Diabetes |
title_sort | impaired endothelial function in preadolescent children with type 1 diabetes |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041207/ https://www.ncbi.nlm.nih.gov/pubmed/21289230 http://dx.doi.org/10.2337/dc10-2134 |
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