Cargando…
Clinical Significance of Urinary Liver-Type Fatty Acid–Binding Protein in Diabetic Nephropathy of Type 2 Diabetic Patients
OBJECTIVE: Urinary liver-type fatty acid–binding protein (L-FABP) is a promising indicator of tubular but not glomerular damage. The aim of this study was to evaluate the clinical usefulness of urinary L-FABP as a prognostic biomarker in impaired diabetic nephropathy in type 2 diabetes. RESEARCH DES...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041209/ https://www.ncbi.nlm.nih.gov/pubmed/21273494 http://dx.doi.org/10.2337/dc10-1392 |
_version_ | 1782198420390281216 |
---|---|
author | Kamijo-Ikemori, Atsuko Sugaya, Takeshi Yasuda, Takashi Kawata, Takehiro Ota, Akio Tatsunami, Shinobu Kaise, Ruriko Ishimitsu, Toshihiko Tanaka, Yasushi Kimura, Kenjiro |
author_facet | Kamijo-Ikemori, Atsuko Sugaya, Takeshi Yasuda, Takashi Kawata, Takehiro Ota, Akio Tatsunami, Shinobu Kaise, Ruriko Ishimitsu, Toshihiko Tanaka, Yasushi Kimura, Kenjiro |
author_sort | Kamijo-Ikemori, Atsuko |
collection | PubMed |
description | OBJECTIVE: Urinary liver-type fatty acid–binding protein (L-FABP) is a promising indicator of tubular but not glomerular damage. The aim of this study was to evaluate the clinical usefulness of urinary L-FABP as a prognostic biomarker in impaired diabetic nephropathy in type 2 diabetes. RESEARCH DESIGN AND METHODS: This investigation involved a cross-sectional and longitudinal analysis of the relationship between urinary L-FABP levels and progressive nephropathy. Urinary L-FABP was measured with enzyme-linked immunosorbent assay. In the cross-sectional analysis, the association of urinary L-FABP, with the severity of diabetic nephropathy, was investigated in 140 patients with type 2 diabetes and in 412 healthy control subjects. Of the patients in the former study, 104 have been followed for 4 years. The progression of diabetic nephropathy was defined as progressive albuminuria, end-stage renal disease, or induction of hemodialysis. RESULTS: Urinary L-FABP levels were progressively increased in subjects with normo-, micro-, or macroalbuminuria and further increased in patients with end-stage renal disease. In the longitudinal analysis, high urinary L-FABP levels were associated with the increase in albuminuria, progression to end-stage renal disease, or induction of hemodialysis. This was particularly demonstrated in the subgroup of patients without renal dysfunction (n = 59), where high urinary L-FABP levels were associated with the progression of diabetic nephropathy. CONCLUSIONS: Urinary L-FABP accurately reflected the severity of diabetic nephropathy in type 2 diabetes, and its level was high in the patients with normoalbuminuria. Moreover, higher urinary L-FABP was a risk factor for progression of diabetic nephropathy. |
format | Text |
id | pubmed-3041209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-30412092012-03-01 Clinical Significance of Urinary Liver-Type Fatty Acid–Binding Protein in Diabetic Nephropathy of Type 2 Diabetic Patients Kamijo-Ikemori, Atsuko Sugaya, Takeshi Yasuda, Takashi Kawata, Takehiro Ota, Akio Tatsunami, Shinobu Kaise, Ruriko Ishimitsu, Toshihiko Tanaka, Yasushi Kimura, Kenjiro Diabetes Care Original Research OBJECTIVE: Urinary liver-type fatty acid–binding protein (L-FABP) is a promising indicator of tubular but not glomerular damage. The aim of this study was to evaluate the clinical usefulness of urinary L-FABP as a prognostic biomarker in impaired diabetic nephropathy in type 2 diabetes. RESEARCH DESIGN AND METHODS: This investigation involved a cross-sectional and longitudinal analysis of the relationship between urinary L-FABP levels and progressive nephropathy. Urinary L-FABP was measured with enzyme-linked immunosorbent assay. In the cross-sectional analysis, the association of urinary L-FABP, with the severity of diabetic nephropathy, was investigated in 140 patients with type 2 diabetes and in 412 healthy control subjects. Of the patients in the former study, 104 have been followed for 4 years. The progression of diabetic nephropathy was defined as progressive albuminuria, end-stage renal disease, or induction of hemodialysis. RESULTS: Urinary L-FABP levels were progressively increased in subjects with normo-, micro-, or macroalbuminuria and further increased in patients with end-stage renal disease. In the longitudinal analysis, high urinary L-FABP levels were associated with the increase in albuminuria, progression to end-stage renal disease, or induction of hemodialysis. This was particularly demonstrated in the subgroup of patients without renal dysfunction (n = 59), where high urinary L-FABP levels were associated with the progression of diabetic nephropathy. CONCLUSIONS: Urinary L-FABP accurately reflected the severity of diabetic nephropathy in type 2 diabetes, and its level was high in the patients with normoalbuminuria. Moreover, higher urinary L-FABP was a risk factor for progression of diabetic nephropathy. American Diabetes Association 2011-03 2011-02-17 /pmc/articles/PMC3041209/ /pubmed/21273494 http://dx.doi.org/10.2337/dc10-1392 Text en © 2011 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Original Research Kamijo-Ikemori, Atsuko Sugaya, Takeshi Yasuda, Takashi Kawata, Takehiro Ota, Akio Tatsunami, Shinobu Kaise, Ruriko Ishimitsu, Toshihiko Tanaka, Yasushi Kimura, Kenjiro Clinical Significance of Urinary Liver-Type Fatty Acid–Binding Protein in Diabetic Nephropathy of Type 2 Diabetic Patients |
title | Clinical Significance of Urinary Liver-Type Fatty Acid–Binding Protein in Diabetic Nephropathy of Type 2 Diabetic Patients |
title_full | Clinical Significance of Urinary Liver-Type Fatty Acid–Binding Protein in Diabetic Nephropathy of Type 2 Diabetic Patients |
title_fullStr | Clinical Significance of Urinary Liver-Type Fatty Acid–Binding Protein in Diabetic Nephropathy of Type 2 Diabetic Patients |
title_full_unstemmed | Clinical Significance of Urinary Liver-Type Fatty Acid–Binding Protein in Diabetic Nephropathy of Type 2 Diabetic Patients |
title_short | Clinical Significance of Urinary Liver-Type Fatty Acid–Binding Protein in Diabetic Nephropathy of Type 2 Diabetic Patients |
title_sort | clinical significance of urinary liver-type fatty acid–binding protein in diabetic nephropathy of type 2 diabetic patients |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041209/ https://www.ncbi.nlm.nih.gov/pubmed/21273494 http://dx.doi.org/10.2337/dc10-1392 |
work_keys_str_mv | AT kamijoikemoriatsuko clinicalsignificanceofurinarylivertypefattyacidbindingproteinindiabeticnephropathyoftype2diabeticpatients AT sugayatakeshi clinicalsignificanceofurinarylivertypefattyacidbindingproteinindiabeticnephropathyoftype2diabeticpatients AT yasudatakashi clinicalsignificanceofurinarylivertypefattyacidbindingproteinindiabeticnephropathyoftype2diabeticpatients AT kawatatakehiro clinicalsignificanceofurinarylivertypefattyacidbindingproteinindiabeticnephropathyoftype2diabeticpatients AT otaakio clinicalsignificanceofurinarylivertypefattyacidbindingproteinindiabeticnephropathyoftype2diabeticpatients AT tatsunamishinobu clinicalsignificanceofurinarylivertypefattyacidbindingproteinindiabeticnephropathyoftype2diabeticpatients AT kaiseruriko clinicalsignificanceofurinarylivertypefattyacidbindingproteinindiabeticnephropathyoftype2diabeticpatients AT ishimitsutoshihiko clinicalsignificanceofurinarylivertypefattyacidbindingproteinindiabeticnephropathyoftype2diabeticpatients AT tanakayasushi clinicalsignificanceofurinarylivertypefattyacidbindingproteinindiabeticnephropathyoftype2diabeticpatients AT kimurakenjiro clinicalsignificanceofurinarylivertypefattyacidbindingproteinindiabeticnephropathyoftype2diabeticpatients |