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Empirical Derivation to Improve the Definition of the Metabolic Syndrome in the Evaluation of Cardiovascular Disease Risk

OBJECTIVE: To examine whether a quantitatively derived metabolic syndrome definition predicts incident cardiovascular disease (CVD) events better than do existing definitions. RESEARCH DESIGN AND METHODS: Data were pooled from the Atherosclerosis Risk in Communities, Cardiovascular Health, and Frami...

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Autores principales: Wildman, Rachel P., McGinn, Aileen P., Kim, Mimi, Muntner, Paul, Wang, Dan, Cohen, Hillel W., Ogorodnikova, Alexandra D., Reynolds, Kristi, Fonseca, Vivian
Formato: Texto
Lenguaje:English
Publicado: American Diabetes Association 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041220/
https://www.ncbi.nlm.nih.gov/pubmed/21285391
http://dx.doi.org/10.2337/dc10-1715
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author Wildman, Rachel P.
McGinn, Aileen P.
Kim, Mimi
Muntner, Paul
Wang, Dan
Cohen, Hillel W.
Ogorodnikova, Alexandra D.
Reynolds, Kristi
Fonseca, Vivian
author_facet Wildman, Rachel P.
McGinn, Aileen P.
Kim, Mimi
Muntner, Paul
Wang, Dan
Cohen, Hillel W.
Ogorodnikova, Alexandra D.
Reynolds, Kristi
Fonseca, Vivian
author_sort Wildman, Rachel P.
collection PubMed
description OBJECTIVE: To examine whether a quantitatively derived metabolic syndrome definition predicts incident cardiovascular disease (CVD) events better than do existing definitions. RESEARCH DESIGN AND METHODS: Data were pooled from the Atherosclerosis Risk in Communities, Cardiovascular Health, and Framingham Offspring studies (n = 20,581). Incident coronary heart disease and stroke events were ascertained over 9 years. RESULTS: The sensitivity for incident CVD events was higher and the specificity lower for the empirically derived versus the Adult Treatment Panel (ATP) III, International Diabetes Federation (IDF), or Harmonized metabolic syndrome definitions (sensitivity/specificity 0.65/0.53 vs. 0.53/0.63, 0.51/0.66, and 0.64/0.56, respectively), resulting in no overall improvement in discrimination. Multivariable-adjusted hazard ratios for incident CVD events were similar across definitions and were 1.7 (95% CI 1.6–1.9) for ATP III, 1.8 (1.6–2.0) for IDF, 1.9 (1.7–2.0) for Harmonized, and 1.7 (1.6–1.9) for the empirically derived definition. CONCLUSIONS: Empirical derivation of the metabolic syndrome definition did not improve CVD discrimination or risk prediction.
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spelling pubmed-30412202012-03-01 Empirical Derivation to Improve the Definition of the Metabolic Syndrome in the Evaluation of Cardiovascular Disease Risk Wildman, Rachel P. McGinn, Aileen P. Kim, Mimi Muntner, Paul Wang, Dan Cohen, Hillel W. Ogorodnikova, Alexandra D. Reynolds, Kristi Fonseca, Vivian Diabetes Care Original Research OBJECTIVE: To examine whether a quantitatively derived metabolic syndrome definition predicts incident cardiovascular disease (CVD) events better than do existing definitions. RESEARCH DESIGN AND METHODS: Data were pooled from the Atherosclerosis Risk in Communities, Cardiovascular Health, and Framingham Offspring studies (n = 20,581). Incident coronary heart disease and stroke events were ascertained over 9 years. RESULTS: The sensitivity for incident CVD events was higher and the specificity lower for the empirically derived versus the Adult Treatment Panel (ATP) III, International Diabetes Federation (IDF), or Harmonized metabolic syndrome definitions (sensitivity/specificity 0.65/0.53 vs. 0.53/0.63, 0.51/0.66, and 0.64/0.56, respectively), resulting in no overall improvement in discrimination. Multivariable-adjusted hazard ratios for incident CVD events were similar across definitions and were 1.7 (95% CI 1.6–1.9) for ATP III, 1.8 (1.6–2.0) for IDF, 1.9 (1.7–2.0) for Harmonized, and 1.7 (1.6–1.9) for the empirically derived definition. CONCLUSIONS: Empirical derivation of the metabolic syndrome definition did not improve CVD discrimination or risk prediction. American Diabetes Association 2011-03 2011-02-17 /pmc/articles/PMC3041220/ /pubmed/21285391 http://dx.doi.org/10.2337/dc10-1715 Text en © 2011 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details.
spellingShingle Original Research
Wildman, Rachel P.
McGinn, Aileen P.
Kim, Mimi
Muntner, Paul
Wang, Dan
Cohen, Hillel W.
Ogorodnikova, Alexandra D.
Reynolds, Kristi
Fonseca, Vivian
Empirical Derivation to Improve the Definition of the Metabolic Syndrome in the Evaluation of Cardiovascular Disease Risk
title Empirical Derivation to Improve the Definition of the Metabolic Syndrome in the Evaluation of Cardiovascular Disease Risk
title_full Empirical Derivation to Improve the Definition of the Metabolic Syndrome in the Evaluation of Cardiovascular Disease Risk
title_fullStr Empirical Derivation to Improve the Definition of the Metabolic Syndrome in the Evaluation of Cardiovascular Disease Risk
title_full_unstemmed Empirical Derivation to Improve the Definition of the Metabolic Syndrome in the Evaluation of Cardiovascular Disease Risk
title_short Empirical Derivation to Improve the Definition of the Metabolic Syndrome in the Evaluation of Cardiovascular Disease Risk
title_sort empirical derivation to improve the definition of the metabolic syndrome in the evaluation of cardiovascular disease risk
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041220/
https://www.ncbi.nlm.nih.gov/pubmed/21285391
http://dx.doi.org/10.2337/dc10-1715
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