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Empirical Derivation to Improve the Definition of the Metabolic Syndrome in the Evaluation of Cardiovascular Disease Risk
OBJECTIVE: To examine whether a quantitatively derived metabolic syndrome definition predicts incident cardiovascular disease (CVD) events better than do existing definitions. RESEARCH DESIGN AND METHODS: Data were pooled from the Atherosclerosis Risk in Communities, Cardiovascular Health, and Frami...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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American Diabetes Association
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041220/ https://www.ncbi.nlm.nih.gov/pubmed/21285391 http://dx.doi.org/10.2337/dc10-1715 |
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author | Wildman, Rachel P. McGinn, Aileen P. Kim, Mimi Muntner, Paul Wang, Dan Cohen, Hillel W. Ogorodnikova, Alexandra D. Reynolds, Kristi Fonseca, Vivian |
author_facet | Wildman, Rachel P. McGinn, Aileen P. Kim, Mimi Muntner, Paul Wang, Dan Cohen, Hillel W. Ogorodnikova, Alexandra D. Reynolds, Kristi Fonseca, Vivian |
author_sort | Wildman, Rachel P. |
collection | PubMed |
description | OBJECTIVE: To examine whether a quantitatively derived metabolic syndrome definition predicts incident cardiovascular disease (CVD) events better than do existing definitions. RESEARCH DESIGN AND METHODS: Data were pooled from the Atherosclerosis Risk in Communities, Cardiovascular Health, and Framingham Offspring studies (n = 20,581). Incident coronary heart disease and stroke events were ascertained over 9 years. RESULTS: The sensitivity for incident CVD events was higher and the specificity lower for the empirically derived versus the Adult Treatment Panel (ATP) III, International Diabetes Federation (IDF), or Harmonized metabolic syndrome definitions (sensitivity/specificity 0.65/0.53 vs. 0.53/0.63, 0.51/0.66, and 0.64/0.56, respectively), resulting in no overall improvement in discrimination. Multivariable-adjusted hazard ratios for incident CVD events were similar across definitions and were 1.7 (95% CI 1.6–1.9) for ATP III, 1.8 (1.6–2.0) for IDF, 1.9 (1.7–2.0) for Harmonized, and 1.7 (1.6–1.9) for the empirically derived definition. CONCLUSIONS: Empirical derivation of the metabolic syndrome definition did not improve CVD discrimination or risk prediction. |
format | Text |
id | pubmed-3041220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | American Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-30412202012-03-01 Empirical Derivation to Improve the Definition of the Metabolic Syndrome in the Evaluation of Cardiovascular Disease Risk Wildman, Rachel P. McGinn, Aileen P. Kim, Mimi Muntner, Paul Wang, Dan Cohen, Hillel W. Ogorodnikova, Alexandra D. Reynolds, Kristi Fonseca, Vivian Diabetes Care Original Research OBJECTIVE: To examine whether a quantitatively derived metabolic syndrome definition predicts incident cardiovascular disease (CVD) events better than do existing definitions. RESEARCH DESIGN AND METHODS: Data were pooled from the Atherosclerosis Risk in Communities, Cardiovascular Health, and Framingham Offspring studies (n = 20,581). Incident coronary heart disease and stroke events were ascertained over 9 years. RESULTS: The sensitivity for incident CVD events was higher and the specificity lower for the empirically derived versus the Adult Treatment Panel (ATP) III, International Diabetes Federation (IDF), or Harmonized metabolic syndrome definitions (sensitivity/specificity 0.65/0.53 vs. 0.53/0.63, 0.51/0.66, and 0.64/0.56, respectively), resulting in no overall improvement in discrimination. Multivariable-adjusted hazard ratios for incident CVD events were similar across definitions and were 1.7 (95% CI 1.6–1.9) for ATP III, 1.8 (1.6–2.0) for IDF, 1.9 (1.7–2.0) for Harmonized, and 1.7 (1.6–1.9) for the empirically derived definition. CONCLUSIONS: Empirical derivation of the metabolic syndrome definition did not improve CVD discrimination or risk prediction. American Diabetes Association 2011-03 2011-02-17 /pmc/articles/PMC3041220/ /pubmed/21285391 http://dx.doi.org/10.2337/dc10-1715 Text en © 2011 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. See http://creativecommons.org/licenses/by-nc-nd/3.0/ for details. |
spellingShingle | Original Research Wildman, Rachel P. McGinn, Aileen P. Kim, Mimi Muntner, Paul Wang, Dan Cohen, Hillel W. Ogorodnikova, Alexandra D. Reynolds, Kristi Fonseca, Vivian Empirical Derivation to Improve the Definition of the Metabolic Syndrome in the Evaluation of Cardiovascular Disease Risk |
title | Empirical Derivation to Improve the Definition of the Metabolic Syndrome in the Evaluation of Cardiovascular Disease Risk |
title_full | Empirical Derivation to Improve the Definition of the Metabolic Syndrome in the Evaluation of Cardiovascular Disease Risk |
title_fullStr | Empirical Derivation to Improve the Definition of the Metabolic Syndrome in the Evaluation of Cardiovascular Disease Risk |
title_full_unstemmed | Empirical Derivation to Improve the Definition of the Metabolic Syndrome in the Evaluation of Cardiovascular Disease Risk |
title_short | Empirical Derivation to Improve the Definition of the Metabolic Syndrome in the Evaluation of Cardiovascular Disease Risk |
title_sort | empirical derivation to improve the definition of the metabolic syndrome in the evaluation of cardiovascular disease risk |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041220/ https://www.ncbi.nlm.nih.gov/pubmed/21285391 http://dx.doi.org/10.2337/dc10-1715 |
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