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Evaluating the Association Between Insulin–Like Growth Factor-1 Values and Short-Term Survival Rates Following Acute Myocardial Infarction

BACKGROUNDS: In recent years, low levels of Insulin-like Growth Factor-1 (IGF-1) have been suggested to be associated with higher risks of developing heart failure and higher long-term mortality rates following Acute Myocardial Infarction (AMI). However, the effect of IGF-1 levels on short-term surv...

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Autores principales: Hajsadeghi, Shokoufeh, Mohseni, Hamed, Moradi, Masoud, Rahmani, Elham, Kordshakeri, Kiarash, Manteghi, Mohammad Javad, Tokazebani, Masoud, Mollahoseini, Reza
Formato: Texto
Lenguaje:English
Publicado: Libertas Academica 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041238/
https://www.ncbi.nlm.nih.gov/pubmed/21344020
http://dx.doi.org/10.4137/CMC.S6629
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author Hajsadeghi, Shokoufeh
Mohseni, Hamed
Moradi, Masoud
Rahmani, Elham
Kordshakeri, Kiarash
Manteghi, Mohammad Javad
Tokazebani, Masoud
Mollahoseini, Reza
author_facet Hajsadeghi, Shokoufeh
Mohseni, Hamed
Moradi, Masoud
Rahmani, Elham
Kordshakeri, Kiarash
Manteghi, Mohammad Javad
Tokazebani, Masoud
Mollahoseini, Reza
author_sort Hajsadeghi, Shokoufeh
collection PubMed
description BACKGROUNDS: In recent years, low levels of Insulin-like Growth Factor-1 (IGF-1) have been suggested to be associated with higher risks of developing heart failure and higher long-term mortality rates following Acute Myocardial Infarction (AMI). However, the effect of IGF-1 levels on short-term survival has been rarely studied. In this study we aimed to assess any possible association between serum IGF-1 concentration following AMI and short-term survival rates. METHODS: In this study, serum total IGF-1 levels were measured in 56 patients within 24 hours following AMI and were compared to 56 individuals with no cardiovascular disease. Patients were followed up to death or discharge from hospital (median = 6 days) and survival curves were compared based on median IGF-1 value. RESULTS: Mean (±SD) of serum IGF-1 levels were 232.73 ng/ml (±81.74) and 211.00 ng/ml (±58.22) in survived and expired patients respectively and the difference was not statistically significant (P value = 0.501). The difference between survival curves was also not statistically significant (P value = 0.246). CONCLUSION: According to findings of this study, serum total IGF-1 concentration does not seem to be associated with short-term survival rates.
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spelling pubmed-30412382011-02-22 Evaluating the Association Between Insulin–Like Growth Factor-1 Values and Short-Term Survival Rates Following Acute Myocardial Infarction Hajsadeghi, Shokoufeh Mohseni, Hamed Moradi, Masoud Rahmani, Elham Kordshakeri, Kiarash Manteghi, Mohammad Javad Tokazebani, Masoud Mollahoseini, Reza Clin Med Insights Cardiol Original Research BACKGROUNDS: In recent years, low levels of Insulin-like Growth Factor-1 (IGF-1) have been suggested to be associated with higher risks of developing heart failure and higher long-term mortality rates following Acute Myocardial Infarction (AMI). However, the effect of IGF-1 levels on short-term survival has been rarely studied. In this study we aimed to assess any possible association between serum IGF-1 concentration following AMI and short-term survival rates. METHODS: In this study, serum total IGF-1 levels were measured in 56 patients within 24 hours following AMI and were compared to 56 individuals with no cardiovascular disease. Patients were followed up to death or discharge from hospital (median = 6 days) and survival curves were compared based on median IGF-1 value. RESULTS: Mean (±SD) of serum IGF-1 levels were 232.73 ng/ml (±81.74) and 211.00 ng/ml (±58.22) in survived and expired patients respectively and the difference was not statistically significant (P value = 0.501). The difference between survival curves was also not statistically significant (P value = 0.246). CONCLUSION: According to findings of this study, serum total IGF-1 concentration does not seem to be associated with short-term survival rates. Libertas Academica 2011-02-03 /pmc/articles/PMC3041238/ /pubmed/21344020 http://dx.doi.org/10.4137/CMC.S6629 Text en © the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited.
spellingShingle Original Research
Hajsadeghi, Shokoufeh
Mohseni, Hamed
Moradi, Masoud
Rahmani, Elham
Kordshakeri, Kiarash
Manteghi, Mohammad Javad
Tokazebani, Masoud
Mollahoseini, Reza
Evaluating the Association Between Insulin–Like Growth Factor-1 Values and Short-Term Survival Rates Following Acute Myocardial Infarction
title Evaluating the Association Between Insulin–Like Growth Factor-1 Values and Short-Term Survival Rates Following Acute Myocardial Infarction
title_full Evaluating the Association Between Insulin–Like Growth Factor-1 Values and Short-Term Survival Rates Following Acute Myocardial Infarction
title_fullStr Evaluating the Association Between Insulin–Like Growth Factor-1 Values and Short-Term Survival Rates Following Acute Myocardial Infarction
title_full_unstemmed Evaluating the Association Between Insulin–Like Growth Factor-1 Values and Short-Term Survival Rates Following Acute Myocardial Infarction
title_short Evaluating the Association Between Insulin–Like Growth Factor-1 Values and Short-Term Survival Rates Following Acute Myocardial Infarction
title_sort evaluating the association between insulin–like growth factor-1 values and short-term survival rates following acute myocardial infarction
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041238/
https://www.ncbi.nlm.nih.gov/pubmed/21344020
http://dx.doi.org/10.4137/CMC.S6629
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