Synthesis and Pharmacological Activities of 6-Glycine Substituted 14-Phenylpropoxymorphinans, a Novel Class of Opioids with High Opioid Receptor Affinities and Antinociceptive Potencies

[Image: see text] The synthesis and the effect of a combination of 6-glycine and 14-phenylpropoxy substitutions in N-methyl- and N-cycloproplymethylmorphinans on biological activities are described. Binding studies revealed that all new 14-phenylpropoxymorphinans (11−18) displayed high affinity to o...

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Detalles Bibliográficos
Autores principales: Spetea, Mariana, Windisch, Petra, Guo, Yan, Bileviciute-Ljungar, Indre, Schütz, Johannes, Asim, Muhammad Faheem, Berzetei-Gurske, Ilona P., Riba, Pal, Kiraly, Kornel, Fürst, Susanna, Al-Khrasani, Mahmoud, Schmidhammer, Helmut
Formato: Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041239/
https://www.ncbi.nlm.nih.gov/pubmed/21235243
http://dx.doi.org/10.1021/jm101211p

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041239/
https://www.ncbi.nlm.nih.gov/pubmed/21235243
http://dx.doi.org/10.1021/jm101211p

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