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Synthesis and Pharmacological Activities of 6-Glycine Substituted 14-Phenylpropoxymorphinans, a Novel Class of Opioids with High Opioid Receptor Affinities and Antinociceptive Potencies

[Image: see text] The synthesis and the effect of a combination of 6-glycine and 14-phenylpropoxy substitutions in N-methyl- and N-cycloproplymethylmorphinans on biological activities are described. Binding studies revealed that all new 14-phenylpropoxymorphinans (11−18) displayed high affinity to o...

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Detalles Bibliográficos
Autores principales:	Spetea, Mariana, Windisch, Petra, Guo, Yan, Bileviciute-Ljungar, Indre, Schütz, Johannes, Asim, Muhammad Faheem, Berzetei-Gurske, Ilona P., Riba, Pal, Kiraly, Kornel, Fürst, Susanna, Al-Khrasani, Mahmoud, Schmidhammer, Helmut
Formato:	Texto
Lenguaje:	English
Publicado:	American Chemical Society 2011
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041239/ https://www.ncbi.nlm.nih.gov/pubmed/21235243 http://dx.doi.org/10.1021/jm101211p

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