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Acquired Gitelman Syndrome
Acquired renal tubular disorder can be observed in various disease processes, especially autoimmune diseases. Gitelman syndrome is an autosomal recessive disease characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria. This disorder is caused by mutation in the SLC12A3 ge...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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The Korean Society of Electrolyte Metabolism
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041481/ https://www.ncbi.nlm.nih.gov/pubmed/21468178 http://dx.doi.org/10.5049/EBP.2009.7.1.5 |
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author | Kim, Yong Kyun Song, Ho Cheol Kim, Yong-Soo Choi, Euy Jin |
author_facet | Kim, Yong Kyun Song, Ho Cheol Kim, Yong-Soo Choi, Euy Jin |
author_sort | Kim, Yong Kyun |
collection | PubMed |
description | Acquired renal tubular disorder can be observed in various disease processes, especially autoimmune diseases. Gitelman syndrome is an autosomal recessive disease characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria. This disorder is caused by mutation in the SLC12A3 gene, which encodes the thiazide-sensitive NaCl cotransporter (NCCT). Acquired Gitelman syndrome has been reported and the majority has been associated with Sjögren's syndrome. The presence of circulating auto-antibodies to NCCT was suggested as a mechanism of acquired Gitelman syndrome. Treatment of acquired Gitelman syndrome was done with supplements of potassium and magnesium and prednisone was effective in some cases. Acquired Gitelman syndrome should be included in the differential diagnosis of renal involvement in patients with autoimmune diseases, especially Sjögren's syndrome. |
format | Text |
id | pubmed-3041481 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | The Korean Society of Electrolyte Metabolism |
record_format | MEDLINE/PubMed |
spelling | pubmed-30414812011-04-05 Acquired Gitelman Syndrome Kim, Yong Kyun Song, Ho Cheol Kim, Yong-Soo Choi, Euy Jin Electrolyte Blood Press Review Article Acquired renal tubular disorder can be observed in various disease processes, especially autoimmune diseases. Gitelman syndrome is an autosomal recessive disease characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria. This disorder is caused by mutation in the SLC12A3 gene, which encodes the thiazide-sensitive NaCl cotransporter (NCCT). Acquired Gitelman syndrome has been reported and the majority has been associated with Sjögren's syndrome. The presence of circulating auto-antibodies to NCCT was suggested as a mechanism of acquired Gitelman syndrome. Treatment of acquired Gitelman syndrome was done with supplements of potassium and magnesium and prednisone was effective in some cases. Acquired Gitelman syndrome should be included in the differential diagnosis of renal involvement in patients with autoimmune diseases, especially Sjögren's syndrome. The Korean Society of Electrolyte Metabolism 2009-06 2009-06-30 /pmc/articles/PMC3041481/ /pubmed/21468178 http://dx.doi.org/10.5049/EBP.2009.7.1.5 Text en Copyright © 2009 The Korean Society of Electrolyte Metabolism http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Kim, Yong Kyun Song, Ho Cheol Kim, Yong-Soo Choi, Euy Jin Acquired Gitelman Syndrome |
title | Acquired Gitelman Syndrome |
title_full | Acquired Gitelman Syndrome |
title_fullStr | Acquired Gitelman Syndrome |
title_full_unstemmed | Acquired Gitelman Syndrome |
title_short | Acquired Gitelman Syndrome |
title_sort | acquired gitelman syndrome |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041481/ https://www.ncbi.nlm.nih.gov/pubmed/21468178 http://dx.doi.org/10.5049/EBP.2009.7.1.5 |
work_keys_str_mv | AT kimyongkyun acquiredgitelmansyndrome AT songhocheol acquiredgitelmansyndrome AT kimyongsoo acquiredgitelmansyndrome AT choieuyjin acquiredgitelmansyndrome |