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Icodextrin Improves the Serum Potassium Profile with the Enhancement of Nutritional Status in Continuous Ambulatory Peritoneal Dialysis Patients

The impact of glucose-free icodextrin (ID) for overnight dwell as compared to conventional glucose-containing dialysate (GD) on potassium (K(+)) metabolism in continuous ambulatory peritoneal dialysis (CAPD) patients has not yet been investigated. Serum K(+) in a total of 255 stable patients (116 on...

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Autores principales: Yi, Joo-Hark, Park, Jae-Il, Choi, Hoon-Young, Lee, Ho-Yung, Han, Sang-Woong, Kim, Ho-Jung
Formato: Texto
Lenguaje:English
Publicado: The Korean Society of Electrolyte Metabolism 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041488/
https://www.ncbi.nlm.nih.gov/pubmed/21468190
http://dx.doi.org/10.5049/EBP.2009.7.2.79
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author Yi, Joo-Hark
Park, Jae-Il
Choi, Hoon-Young
Lee, Ho-Yung
Han, Sang-Woong
Kim, Ho-Jung
author_facet Yi, Joo-Hark
Park, Jae-Il
Choi, Hoon-Young
Lee, Ho-Yung
Han, Sang-Woong
Kim, Ho-Jung
author_sort Yi, Joo-Hark
collection PubMed
description The impact of glucose-free icodextrin (ID) for overnight dwell as compared to conventional glucose-containing dialysate (GD) on potassium (K(+)) metabolism in continuous ambulatory peritoneal dialysis (CAPD) patients has not yet been investigated. Serum K(+) in a total of 255 stable patients (116 on GD and 139 on ID) on CAPD for more than 6 months and in 139 patients on ID before and after ID use (Pre-ID and Post-ID) were observed along with nutritional markers in a 2-year study period (Jan. 2006 to Dec. 2007). The prevalence of hypokalemia was similar between patients on GD and ID (16.7% vs 17.3%), but was lower on Post-ID than Pre-ID (17.3% vs 20.5%) without statistic significance. The mean serum K(+) level was higher on ID than on GD (P<0.05) as well as Post-ID than Pre-ID (P<0.001). In the multivariate analysis, serum K(+) levels were positively correlated with serum albumin, and creatinine in all patients (P<0.05), and ID-use in younger patients (age≤56, P<0.001). Serum albumin, creatinine, total CO(2), and body mass index were significantly higher on Post-ID than Pre-ID. Icodextrin dialysate for chronic overnight dwell could increase serum K(+) levels and lower the prevalence of hypokalemia compared to conventional glucose-containing dialysate. The improved chronic K(+) balance in CAPD patients on icodextrin could be related to enhanced nutritional status rather than its impact on acute intracellular K(+) redistribution.
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spelling pubmed-30414882011-04-05 Icodextrin Improves the Serum Potassium Profile with the Enhancement of Nutritional Status in Continuous Ambulatory Peritoneal Dialysis Patients Yi, Joo-Hark Park, Jae-Il Choi, Hoon-Young Lee, Ho-Yung Han, Sang-Woong Kim, Ho-Jung Electrolyte Blood Press Original Investigation The impact of glucose-free icodextrin (ID) for overnight dwell as compared to conventional glucose-containing dialysate (GD) on potassium (K(+)) metabolism in continuous ambulatory peritoneal dialysis (CAPD) patients has not yet been investigated. Serum K(+) in a total of 255 stable patients (116 on GD and 139 on ID) on CAPD for more than 6 months and in 139 patients on ID before and after ID use (Pre-ID and Post-ID) were observed along with nutritional markers in a 2-year study period (Jan. 2006 to Dec. 2007). The prevalence of hypokalemia was similar between patients on GD and ID (16.7% vs 17.3%), but was lower on Post-ID than Pre-ID (17.3% vs 20.5%) without statistic significance. The mean serum K(+) level was higher on ID than on GD (P<0.05) as well as Post-ID than Pre-ID (P<0.001). In the multivariate analysis, serum K(+) levels were positively correlated with serum albumin, and creatinine in all patients (P<0.05), and ID-use in younger patients (age≤56, P<0.001). Serum albumin, creatinine, total CO(2), and body mass index were significantly higher on Post-ID than Pre-ID. Icodextrin dialysate for chronic overnight dwell could increase serum K(+) levels and lower the prevalence of hypokalemia compared to conventional glucose-containing dialysate. The improved chronic K(+) balance in CAPD patients on icodextrin could be related to enhanced nutritional status rather than its impact on acute intracellular K(+) redistribution. The Korean Society of Electrolyte Metabolism 2009-12 2009-12-31 /pmc/articles/PMC3041488/ /pubmed/21468190 http://dx.doi.org/10.5049/EBP.2009.7.2.79 Text en Copyright © 2009 The Korean Society of Electrolyte Metabolism http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Investigation
Yi, Joo-Hark
Park, Jae-Il
Choi, Hoon-Young
Lee, Ho-Yung
Han, Sang-Woong
Kim, Ho-Jung
Icodextrin Improves the Serum Potassium Profile with the Enhancement of Nutritional Status in Continuous Ambulatory Peritoneal Dialysis Patients
title Icodextrin Improves the Serum Potassium Profile with the Enhancement of Nutritional Status in Continuous Ambulatory Peritoneal Dialysis Patients
title_full Icodextrin Improves the Serum Potassium Profile with the Enhancement of Nutritional Status in Continuous Ambulatory Peritoneal Dialysis Patients
title_fullStr Icodextrin Improves the Serum Potassium Profile with the Enhancement of Nutritional Status in Continuous Ambulatory Peritoneal Dialysis Patients
title_full_unstemmed Icodextrin Improves the Serum Potassium Profile with the Enhancement of Nutritional Status in Continuous Ambulatory Peritoneal Dialysis Patients
title_short Icodextrin Improves the Serum Potassium Profile with the Enhancement of Nutritional Status in Continuous Ambulatory Peritoneal Dialysis Patients
title_sort icodextrin improves the serum potassium profile with the enhancement of nutritional status in continuous ambulatory peritoneal dialysis patients
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041488/
https://www.ncbi.nlm.nih.gov/pubmed/21468190
http://dx.doi.org/10.5049/EBP.2009.7.2.79
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