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Shared Genomics: Developing an accessible integrated analysis platform for Genome-Wide Association Studies

Increasingly, genome-wide association studies are being used to identify positions within the human genome that have a link with a disease condition. The number of genomic locations studied means that computationally intensive and bioinformatic intensive solutions will have to be used in the analysi...

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Detalles Bibliográficos
Autores principales: Hoyle, David, Delderfield, Mark, Kitching, Lee, Smith, Gareth, Buchan, Iain
Formato: Texto
Lenguaje:English
Publicado: American Medical Informatics Association 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041536/
https://www.ncbi.nlm.nih.gov/pubmed/21347139
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author Hoyle, David
Delderfield, Mark
Kitching, Lee
Smith, Gareth
Buchan, Iain
author_facet Hoyle, David
Delderfield, Mark
Kitching, Lee
Smith, Gareth
Buchan, Iain
author_sort Hoyle, David
collection PubMed
description Increasingly, genome-wide association studies are being used to identify positions within the human genome that have a link with a disease condition. The number of genomic locations studied means that computationally intensive and bioinformatic intensive solutions will have to be used in the analysis of these data sets. In this paper we present an integrated Workbench that provides user-friendly access to parallelized statistical genetics analysis codes for clinical researchers. In addition we biologically annotate statistical analysis results through the reuse of existing bionformatic Taverna workflows.
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spelling pubmed-30415362011-02-23 Shared Genomics: Developing an accessible integrated analysis platform for Genome-Wide Association Studies Hoyle, David Delderfield, Mark Kitching, Lee Smith, Gareth Buchan, Iain Summit on Translat Bioinforma Articles Increasingly, genome-wide association studies are being used to identify positions within the human genome that have a link with a disease condition. The number of genomic locations studied means that computationally intensive and bioinformatic intensive solutions will have to be used in the analysis of these data sets. In this paper we present an integrated Workbench that provides user-friendly access to parallelized statistical genetics analysis codes for clinical researchers. In addition we biologically annotate statistical analysis results through the reuse of existing bionformatic Taverna workflows. American Medical Informatics Association 2010-03-01 /pmc/articles/PMC3041536/ /pubmed/21347139 Text en ©2010 AMIA - All rights reserved. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose
spellingShingle Articles
Hoyle, David
Delderfield, Mark
Kitching, Lee
Smith, Gareth
Buchan, Iain
Shared Genomics: Developing an accessible integrated analysis platform for Genome-Wide Association Studies
title Shared Genomics: Developing an accessible integrated analysis platform for Genome-Wide Association Studies
title_full Shared Genomics: Developing an accessible integrated analysis platform for Genome-Wide Association Studies
title_fullStr Shared Genomics: Developing an accessible integrated analysis platform for Genome-Wide Association Studies
title_full_unstemmed Shared Genomics: Developing an accessible integrated analysis platform for Genome-Wide Association Studies
title_short Shared Genomics: Developing an accessible integrated analysis platform for Genome-Wide Association Studies
title_sort shared genomics: developing an accessible integrated analysis platform for genome-wide association studies
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041536/
https://www.ncbi.nlm.nih.gov/pubmed/21347139
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