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IL-2 Suppression of IL-12p70 by a Recombinant HSV-1 Expressing IL-2 Induces T-Cell Auto-Reactivity and CNS Demyelination

To evaluate the role of cellular infiltrates in CNS demyelination in immunocompetent mice, we have used a model of multiple sclerosis (MS) in which different strains of mice are infected with a recombinant HSV-1 expressing IL-2. Histologic examination of the mice infected with HSV-IL-2 demonstrates...

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Detalles Bibliográficos
Autores principales:	Zandian, Mandana, Mott, Kevin R., Allen, Sariah J., Chen, Shuang, Arditi, Moshe, Ghiasi, Homayon
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041759/ https://www.ncbi.nlm.nih.gov/pubmed/21364747 http://dx.doi.org/10.1371/journal.pone.0016820

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