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BCR-ABL1-independent PI3Kinase activation causing imatinib-resistance

BACKGROUND: The BCR-ABL1 translocation occurs in chronic myeloid leukemia (CML) and in 25% of cases with acute lymphoblastic leukemia (ALL). The advent of tyrosine kinase inhibitors (TKI) has fundamentally changed the treatment of CML. However, TKI are not equally effective for treating ALL. Further...

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Detalles Bibliográficos
Autores principales:	Quentmeier, Hilmar, Eberth, Sonja, Romani, Julia, Zaborski, Margarete, Drexler, Hans G
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041785/ https://www.ncbi.nlm.nih.gov/pubmed/21299849 http://dx.doi.org/10.1186/1756-8722-4-6

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