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Clinical emergence of neurometastatic merkel cell carcinoma: a surgical case series and literature review

Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine neoplasm of possible viral origin and is known for its aggressive behavior. The incidence of MCC has increased in the last 15 years. Merkel cell carcinoma has the potential to metastasize, but rarely involves the central nervous system....

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Autores principales: Bailey, Thomasina L., Fung, Maxwell A., Gandour-Edwards, Regina, Ellis, William G., Schrot, Rudolph J.
Formato: Texto
Lenguaje:English
Publicado: Springer US 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041920/
https://www.ncbi.nlm.nih.gov/pubmed/20668913
http://dx.doi.org/10.1007/s11060-010-0304-8
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author Bailey, Thomasina L.
Fung, Maxwell A.
Gandour-Edwards, Regina
Ellis, William G.
Schrot, Rudolph J.
author_facet Bailey, Thomasina L.
Fung, Maxwell A.
Gandour-Edwards, Regina
Ellis, William G.
Schrot, Rudolph J.
author_sort Bailey, Thomasina L.
collection PubMed
description Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine neoplasm of possible viral origin and is known for its aggressive behavior. The incidence of MCC has increased in the last 15 years. Merkel cell carcinoma has the potential to metastasize, but rarely involves the central nervous system. Herein, we report three consecutive surgical cases of MCC presenting at a single institution within 1 year. We used intracavitary BCNU wafers (Gliadel(®)) in two cases. Pathological features, including CK20 positivity, consistent with MCC, were present in all cases. We found 33 published cases of MCC with CNS involvement. We suggest that the incidence of neurometastatic MCC may be increasing, parallel to the increasing incidence of primary MCC. We propose a role for intracavitary BCNU wafers in the treatment of intra-axial neurometastatic MCC.
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spelling pubmed-30419202011-03-29 Clinical emergence of neurometastatic merkel cell carcinoma: a surgical case series and literature review Bailey, Thomasina L. Fung, Maxwell A. Gandour-Edwards, Regina Ellis, William G. Schrot, Rudolph J. J Neurooncol Clinical Study - Patient Studies Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine neoplasm of possible viral origin and is known for its aggressive behavior. The incidence of MCC has increased in the last 15 years. Merkel cell carcinoma has the potential to metastasize, but rarely involves the central nervous system. Herein, we report three consecutive surgical cases of MCC presenting at a single institution within 1 year. We used intracavitary BCNU wafers (Gliadel(®)) in two cases. Pathological features, including CK20 positivity, consistent with MCC, were present in all cases. We found 33 published cases of MCC with CNS involvement. We suggest that the incidence of neurometastatic MCC may be increasing, parallel to the increasing incidence of primary MCC. We propose a role for intracavitary BCNU wafers in the treatment of intra-axial neurometastatic MCC. Springer US 2010-07-29 2011 /pmc/articles/PMC3041920/ /pubmed/20668913 http://dx.doi.org/10.1007/s11060-010-0304-8 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Clinical Study - Patient Studies
Bailey, Thomasina L.
Fung, Maxwell A.
Gandour-Edwards, Regina
Ellis, William G.
Schrot, Rudolph J.
Clinical emergence of neurometastatic merkel cell carcinoma: a surgical case series and literature review
title Clinical emergence of neurometastatic merkel cell carcinoma: a surgical case series and literature review
title_full Clinical emergence of neurometastatic merkel cell carcinoma: a surgical case series and literature review
title_fullStr Clinical emergence of neurometastatic merkel cell carcinoma: a surgical case series and literature review
title_full_unstemmed Clinical emergence of neurometastatic merkel cell carcinoma: a surgical case series and literature review
title_short Clinical emergence of neurometastatic merkel cell carcinoma: a surgical case series and literature review
title_sort clinical emergence of neurometastatic merkel cell carcinoma: a surgical case series and literature review
topic Clinical Study - Patient Studies
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3041920/
https://www.ncbi.nlm.nih.gov/pubmed/20668913
http://dx.doi.org/10.1007/s11060-010-0304-8
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