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2011: the immune hallmarks of cancer
Ten years after the publication of the position paper “The hallmarks of cancer” (Hanahan and Weinberg Cell 100:57–70, 2000), it has become increasingly clear that mutated cells on their way to giving rise to a tumor have also to learn how to thrive in a chronically inflamed microenvironment, evade i...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Springer-Verlag
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042096/ https://www.ncbi.nlm.nih.gov/pubmed/21267721 http://dx.doi.org/10.1007/s00262-010-0968-0 |
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author | Cavallo, Federica De Giovanni, Carla Nanni, Patrizia Forni, Guido Lollini, Pier-Luigi |
author_facet | Cavallo, Federica De Giovanni, Carla Nanni, Patrizia Forni, Guido Lollini, Pier-Luigi |
author_sort | Cavallo, Federica |
collection | PubMed |
description | Ten years after the publication of the position paper “The hallmarks of cancer” (Hanahan and Weinberg Cell 100:57–70, 2000), it has become increasingly clear that mutated cells on their way to giving rise to a tumor have also to learn how to thrive in a chronically inflamed microenvironment, evade immune recognition, and suppress immune reactivity. Genetic and molecular definition of these three immune hallmarks of cancer offers the opportunity to learn how to deploy specific countermeasures to reverse the situation in favor of the immune system and, eventually, the patient. This new information could be channeled to address what seem to be the three major hallmarks for the immune control of cancer progression: effective procedures to activate immune reactivity; characterization of not-disposable oncoantigens; and counteraction of immune suppression. |
format | Text |
id | pubmed-3042096 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-30420962011-03-29 2011: the immune hallmarks of cancer Cavallo, Federica De Giovanni, Carla Nanni, Patrizia Forni, Guido Lollini, Pier-Luigi Cancer Immunol Immunother Symposium-In-Writing Ten years after the publication of the position paper “The hallmarks of cancer” (Hanahan and Weinberg Cell 100:57–70, 2000), it has become increasingly clear that mutated cells on their way to giving rise to a tumor have also to learn how to thrive in a chronically inflamed microenvironment, evade immune recognition, and suppress immune reactivity. Genetic and molecular definition of these three immune hallmarks of cancer offers the opportunity to learn how to deploy specific countermeasures to reverse the situation in favor of the immune system and, eventually, the patient. This new information could be channeled to address what seem to be the three major hallmarks for the immune control of cancer progression: effective procedures to activate immune reactivity; characterization of not-disposable oncoantigens; and counteraction of immune suppression. Springer-Verlag 2011-01-26 2011 /pmc/articles/PMC3042096/ /pubmed/21267721 http://dx.doi.org/10.1007/s00262-010-0968-0 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Symposium-In-Writing Cavallo, Federica De Giovanni, Carla Nanni, Patrizia Forni, Guido Lollini, Pier-Luigi 2011: the immune hallmarks of cancer |
title | 2011: the immune hallmarks of cancer |
title_full | 2011: the immune hallmarks of cancer |
title_fullStr | 2011: the immune hallmarks of cancer |
title_full_unstemmed | 2011: the immune hallmarks of cancer |
title_short | 2011: the immune hallmarks of cancer |
title_sort | 2011: the immune hallmarks of cancer |
topic | Symposium-In-Writing |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042096/ https://www.ncbi.nlm.nih.gov/pubmed/21267721 http://dx.doi.org/10.1007/s00262-010-0968-0 |
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