Cargando…

2011: the immune hallmarks of cancer

Ten years after the publication of the position paper “The hallmarks of cancer” (Hanahan and Weinberg Cell 100:57–70, 2000), it has become increasingly clear that mutated cells on their way to giving rise to a tumor have also to learn how to thrive in a chronically inflamed microenvironment, evade i...

Descripción completa

Detalles Bibliográficos
Autores principales: Cavallo, Federica, De Giovanni, Carla, Nanni, Patrizia, Forni, Guido, Lollini, Pier-Luigi
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042096/
https://www.ncbi.nlm.nih.gov/pubmed/21267721
http://dx.doi.org/10.1007/s00262-010-0968-0
_version_ 1782198509602078720
author Cavallo, Federica
De Giovanni, Carla
Nanni, Patrizia
Forni, Guido
Lollini, Pier-Luigi
author_facet Cavallo, Federica
De Giovanni, Carla
Nanni, Patrizia
Forni, Guido
Lollini, Pier-Luigi
author_sort Cavallo, Federica
collection PubMed
description Ten years after the publication of the position paper “The hallmarks of cancer” (Hanahan and Weinberg Cell 100:57–70, 2000), it has become increasingly clear that mutated cells on their way to giving rise to a tumor have also to learn how to thrive in a chronically inflamed microenvironment, evade immune recognition, and suppress immune reactivity. Genetic and molecular definition of these three immune hallmarks of cancer offers the opportunity to learn how to deploy specific countermeasures to reverse the situation in favor of the immune system and, eventually, the patient. This new information could be channeled to address what seem to be the three major hallmarks for the immune control of cancer progression: effective procedures to activate immune reactivity; characterization of not-disposable oncoantigens; and counteraction of immune suppression.
format Text
id pubmed-3042096
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Springer-Verlag
record_format MEDLINE/PubMed
spelling pubmed-30420962011-03-29 2011: the immune hallmarks of cancer Cavallo, Federica De Giovanni, Carla Nanni, Patrizia Forni, Guido Lollini, Pier-Luigi Cancer Immunol Immunother Symposium-In-Writing Ten years after the publication of the position paper “The hallmarks of cancer” (Hanahan and Weinberg Cell 100:57–70, 2000), it has become increasingly clear that mutated cells on their way to giving rise to a tumor have also to learn how to thrive in a chronically inflamed microenvironment, evade immune recognition, and suppress immune reactivity. Genetic and molecular definition of these three immune hallmarks of cancer offers the opportunity to learn how to deploy specific countermeasures to reverse the situation in favor of the immune system and, eventually, the patient. This new information could be channeled to address what seem to be the three major hallmarks for the immune control of cancer progression: effective procedures to activate immune reactivity; characterization of not-disposable oncoantigens; and counteraction of immune suppression. Springer-Verlag 2011-01-26 2011 /pmc/articles/PMC3042096/ /pubmed/21267721 http://dx.doi.org/10.1007/s00262-010-0968-0 Text en © The Author(s) 2011 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Symposium-In-Writing
Cavallo, Federica
De Giovanni, Carla
Nanni, Patrizia
Forni, Guido
Lollini, Pier-Luigi
2011: the immune hallmarks of cancer
title 2011: the immune hallmarks of cancer
title_full 2011: the immune hallmarks of cancer
title_fullStr 2011: the immune hallmarks of cancer
title_full_unstemmed 2011: the immune hallmarks of cancer
title_short 2011: the immune hallmarks of cancer
title_sort 2011: the immune hallmarks of cancer
topic Symposium-In-Writing
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042096/
https://www.ncbi.nlm.nih.gov/pubmed/21267721
http://dx.doi.org/10.1007/s00262-010-0968-0
work_keys_str_mv AT cavallofederica 2011theimmunehallmarksofcancer
AT degiovannicarla 2011theimmunehallmarksofcancer
AT nannipatrizia 2011theimmunehallmarksofcancer
AT forniguido 2011theimmunehallmarksofcancer
AT lollinipierluigi 2011theimmunehallmarksofcancer