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MicroRNA Expression in Selected Carcinomas of the Gastrointestinal Tract
MicroRNAs (miRNAs) comprise a recently discovered class of small, 18–25 nucleotide, noncoding RNA sequences that regulate gene expression at the posttranscriptional level by binding to and inhibiting the translation of target messenger RNAs (mRNAs). Characteristic patterns of miRNA expression have b...
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Formato: | Texto |
Lenguaje: | English |
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SAGE-Hindawi Access to Research
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042618/ https://www.ncbi.nlm.nih.gov/pubmed/21403819 http://dx.doi.org/10.4061/2011/124608 |
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author | Panarelli, Nicole C. Yantiss, Rhonda K. |
author_facet | Panarelli, Nicole C. Yantiss, Rhonda K. |
author_sort | Panarelli, Nicole C. |
collection | PubMed |
description | MicroRNAs (miRNAs) comprise a recently discovered class of small, 18–25 nucleotide, noncoding RNA sequences that regulate gene expression at the posttranscriptional level by binding to and inhibiting the translation of target messenger RNAs (mRNAs). Characteristic patterns of miRNA expression have been described in several malignancies of the gastrointestinal tract, and numerous investigators have demonstrated interactions between specific miRNA species and target oncogenes or tumor-suppressor genes. It is clear that miRNAs play an important role in regulating expression of a number of genes involved in gastrointestinal carcinogenesis, and, thus, these molecules may represent either diagnostic markers of, or therapeutic targets for, some types of malignancy. This paper summarizes the literature regarding miRNA expression in carcinomas of the colon, pancreas, and liver and discusses some of the mechanisms by which these molecules participate in gastrointestinal oncogenesis. |
format | Text |
id | pubmed-3042618 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-30426182011-03-14 MicroRNA Expression in Selected Carcinomas of the Gastrointestinal Tract Panarelli, Nicole C. Yantiss, Rhonda K. Patholog Res Int Review Article MicroRNAs (miRNAs) comprise a recently discovered class of small, 18–25 nucleotide, noncoding RNA sequences that regulate gene expression at the posttranscriptional level by binding to and inhibiting the translation of target messenger RNAs (mRNAs). Characteristic patterns of miRNA expression have been described in several malignancies of the gastrointestinal tract, and numerous investigators have demonstrated interactions between specific miRNA species and target oncogenes or tumor-suppressor genes. It is clear that miRNAs play an important role in regulating expression of a number of genes involved in gastrointestinal carcinogenesis, and, thus, these molecules may represent either diagnostic markers of, or therapeutic targets for, some types of malignancy. This paper summarizes the literature regarding miRNA expression in carcinomas of the colon, pancreas, and liver and discusses some of the mechanisms by which these molecules participate in gastrointestinal oncogenesis. SAGE-Hindawi Access to Research 2011-02-13 /pmc/articles/PMC3042618/ /pubmed/21403819 http://dx.doi.org/10.4061/2011/124608 Text en Copyright © 2011 N. C. Panarelli and R. K. Yantiss. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Panarelli, Nicole C. Yantiss, Rhonda K. MicroRNA Expression in Selected Carcinomas of the Gastrointestinal Tract |
title | MicroRNA Expression in Selected Carcinomas of the Gastrointestinal Tract |
title_full | MicroRNA Expression in Selected Carcinomas of the Gastrointestinal Tract |
title_fullStr | MicroRNA Expression in Selected Carcinomas of the Gastrointestinal Tract |
title_full_unstemmed | MicroRNA Expression in Selected Carcinomas of the Gastrointestinal Tract |
title_short | MicroRNA Expression in Selected Carcinomas of the Gastrointestinal Tract |
title_sort | microrna expression in selected carcinomas of the gastrointestinal tract |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042618/ https://www.ncbi.nlm.nih.gov/pubmed/21403819 http://dx.doi.org/10.4061/2011/124608 |
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