Cargando…
Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available Data
Adaptive immune responses associated with allergic reactions recognize antigens from a broad spectrum of plants and animals. Herein a meta-analysis was performed on allergy-related data from the immune epitope database (IEDB) to provide a current inventory and highlight knowledge gaps and areas for...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042621/ https://www.ncbi.nlm.nih.gov/pubmed/21403821 http://dx.doi.org/10.1155/2010/628026 |
_version_ | 1782198552976424960 |
---|---|
author | Vaughan, Kerrie Greenbaum, Jason Kim, Yohan Vita, Randi Chung, Jo Peters, Bjoern Broide, David Goodman, Richard Grey, Howard Sette, Alessandro |
author_facet | Vaughan, Kerrie Greenbaum, Jason Kim, Yohan Vita, Randi Chung, Jo Peters, Bjoern Broide, David Goodman, Richard Grey, Howard Sette, Alessandro |
author_sort | Vaughan, Kerrie |
collection | PubMed |
description | Adaptive immune responses associated with allergic reactions recognize antigens from a broad spectrum of plants and animals. Herein a meta-analysis was performed on allergy-related data from the immune epitope database (IEDB) to provide a current inventory and highlight knowledge gaps and areas for future work. The analysis identified over 4,500 allergy-related epitopes derived from 270 different allergens. Overall, the distribution of the data followed expectations based on the nature of allergic responses. Namely, the majority of epitopes were defined for B cells/antibodies and IgE-mediated reactivity, and relatively fewer T-cell epitopes, mostly CD4(+)/class II. Interestingly, the majority of food allergen epitopes were B-cells epitopes whereas a fairly even number of B- and T-cell epitopes were defined for airborne allergens. In addition, epitopes from nonhumans hosts were mostly T-cell epitopes. Overall, coverage of known allergens is sparse with data available for only ~17% of all allergens listed by the IUIS database. Thus, further research would be required to provide a more balanced representation across different allergen categories. Furthermore, inclusion of nonpeptidic epitopes in the IEDB also allows for inventory and analysis of immunological data associated with drug and contact allergen epitopes. Finally, our analysis also underscores that only a handful of epitopes have thus far been investigated for their immunotherapeutic potential. |
format | Text |
id | pubmed-3042621 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30426212011-03-14 Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available Data Vaughan, Kerrie Greenbaum, Jason Kim, Yohan Vita, Randi Chung, Jo Peters, Bjoern Broide, David Goodman, Richard Grey, Howard Sette, Alessandro J Allergy (Cairo) Research Article Adaptive immune responses associated with allergic reactions recognize antigens from a broad spectrum of plants and animals. Herein a meta-analysis was performed on allergy-related data from the immune epitope database (IEDB) to provide a current inventory and highlight knowledge gaps and areas for future work. The analysis identified over 4,500 allergy-related epitopes derived from 270 different allergens. Overall, the distribution of the data followed expectations based on the nature of allergic responses. Namely, the majority of epitopes were defined for B cells/antibodies and IgE-mediated reactivity, and relatively fewer T-cell epitopes, mostly CD4(+)/class II. Interestingly, the majority of food allergen epitopes were B-cells epitopes whereas a fairly even number of B- and T-cell epitopes were defined for airborne allergens. In addition, epitopes from nonhumans hosts were mostly T-cell epitopes. Overall, coverage of known allergens is sparse with data available for only ~17% of all allergens listed by the IUIS database. Thus, further research would be required to provide a more balanced representation across different allergen categories. Furthermore, inclusion of nonpeptidic epitopes in the IEDB also allows for inventory and analysis of immunological data associated with drug and contact allergen epitopes. Finally, our analysis also underscores that only a handful of epitopes have thus far been investigated for their immunotherapeutic potential. Hindawi Publishing Corporation 2010 2011-02-13 /pmc/articles/PMC3042621/ /pubmed/21403821 http://dx.doi.org/10.1155/2010/628026 Text en Copyright © 2010 Kerrie Vaughan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Vaughan, Kerrie Greenbaum, Jason Kim, Yohan Vita, Randi Chung, Jo Peters, Bjoern Broide, David Goodman, Richard Grey, Howard Sette, Alessandro Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available Data |
title | Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available Data |
title_full | Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available Data |
title_fullStr | Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available Data |
title_full_unstemmed | Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available Data |
title_short | Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available Data |
title_sort | towards defining molecular determinants recognized by adaptive immunity in allergic disease: an inventory of the available data |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042621/ https://www.ncbi.nlm.nih.gov/pubmed/21403821 http://dx.doi.org/10.1155/2010/628026 |
work_keys_str_mv | AT vaughankerrie towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata AT greenbaumjason towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata AT kimyohan towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata AT vitarandi towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata AT chungjo towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata AT petersbjoern towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata AT broidedavid towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata AT goodmanrichard towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata AT greyhoward towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata AT settealessandro towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata |