Cargando…

Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available Data

Adaptive immune responses associated with allergic reactions recognize antigens from a broad spectrum of plants and animals. Herein a meta-analysis was performed on allergy-related data from the immune epitope database (IEDB) to provide a current inventory and highlight knowledge gaps and areas for...

Descripción completa

Detalles Bibliográficos
Autores principales: Vaughan, Kerrie, Greenbaum, Jason, Kim, Yohan, Vita, Randi, Chung, Jo, Peters, Bjoern, Broide, David, Goodman, Richard, Grey, Howard, Sette, Alessandro
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042621/
https://www.ncbi.nlm.nih.gov/pubmed/21403821
http://dx.doi.org/10.1155/2010/628026
_version_ 1782198552976424960
author Vaughan, Kerrie
Greenbaum, Jason
Kim, Yohan
Vita, Randi
Chung, Jo
Peters, Bjoern
Broide, David
Goodman, Richard
Grey, Howard
Sette, Alessandro
author_facet Vaughan, Kerrie
Greenbaum, Jason
Kim, Yohan
Vita, Randi
Chung, Jo
Peters, Bjoern
Broide, David
Goodman, Richard
Grey, Howard
Sette, Alessandro
author_sort Vaughan, Kerrie
collection PubMed
description Adaptive immune responses associated with allergic reactions recognize antigens from a broad spectrum of plants and animals. Herein a meta-analysis was performed on allergy-related data from the immune epitope database (IEDB) to provide a current inventory and highlight knowledge gaps and areas for future work. The analysis identified over 4,500 allergy-related epitopes derived from 270 different allergens. Overall, the distribution of the data followed expectations based on the nature of allergic responses. Namely, the majority of epitopes were defined for B cells/antibodies and IgE-mediated reactivity, and relatively fewer T-cell epitopes, mostly CD4(+)/class II. Interestingly, the majority of food allergen epitopes were B-cells epitopes whereas a fairly even number of B- and T-cell epitopes were defined for airborne allergens. In addition, epitopes from nonhumans hosts were mostly T-cell epitopes. Overall, coverage of known allergens is sparse with data available for only ~17% of all allergens listed by the IUIS database. Thus, further research would be required to provide a more balanced representation across different allergen categories. Furthermore, inclusion of nonpeptidic epitopes in the IEDB also allows for inventory and analysis of immunological data associated with drug and contact allergen epitopes. Finally, our analysis also underscores that only a handful of epitopes have thus far been investigated for their immunotherapeutic potential.
format Text
id pubmed-3042621
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-30426212011-03-14 Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available Data Vaughan, Kerrie Greenbaum, Jason Kim, Yohan Vita, Randi Chung, Jo Peters, Bjoern Broide, David Goodman, Richard Grey, Howard Sette, Alessandro J Allergy (Cairo) Research Article Adaptive immune responses associated with allergic reactions recognize antigens from a broad spectrum of plants and animals. Herein a meta-analysis was performed on allergy-related data from the immune epitope database (IEDB) to provide a current inventory and highlight knowledge gaps and areas for future work. The analysis identified over 4,500 allergy-related epitopes derived from 270 different allergens. Overall, the distribution of the data followed expectations based on the nature of allergic responses. Namely, the majority of epitopes were defined for B cells/antibodies and IgE-mediated reactivity, and relatively fewer T-cell epitopes, mostly CD4(+)/class II. Interestingly, the majority of food allergen epitopes were B-cells epitopes whereas a fairly even number of B- and T-cell epitopes were defined for airborne allergens. In addition, epitopes from nonhumans hosts were mostly T-cell epitopes. Overall, coverage of known allergens is sparse with data available for only ~17% of all allergens listed by the IUIS database. Thus, further research would be required to provide a more balanced representation across different allergen categories. Furthermore, inclusion of nonpeptidic epitopes in the IEDB also allows for inventory and analysis of immunological data associated with drug and contact allergen epitopes. Finally, our analysis also underscores that only a handful of epitopes have thus far been investigated for their immunotherapeutic potential. Hindawi Publishing Corporation 2010 2011-02-13 /pmc/articles/PMC3042621/ /pubmed/21403821 http://dx.doi.org/10.1155/2010/628026 Text en Copyright © 2010 Kerrie Vaughan et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Vaughan, Kerrie
Greenbaum, Jason
Kim, Yohan
Vita, Randi
Chung, Jo
Peters, Bjoern
Broide, David
Goodman, Richard
Grey, Howard
Sette, Alessandro
Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available Data
title Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available Data
title_full Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available Data
title_fullStr Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available Data
title_full_unstemmed Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available Data
title_short Towards Defining Molecular Determinants Recognized by Adaptive Immunity in Allergic Disease: An Inventory of the Available Data
title_sort towards defining molecular determinants recognized by adaptive immunity in allergic disease: an inventory of the available data
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042621/
https://www.ncbi.nlm.nih.gov/pubmed/21403821
http://dx.doi.org/10.1155/2010/628026
work_keys_str_mv AT vaughankerrie towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata
AT greenbaumjason towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata
AT kimyohan towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata
AT vitarandi towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata
AT chungjo towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata
AT petersbjoern towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata
AT broidedavid towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata
AT goodmanrichard towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata
AT greyhoward towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata
AT settealessandro towardsdefiningmoleculardeterminantsrecognizedbyadaptiveimmunityinallergicdiseaseaninventoryoftheavailabledata