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Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents
Adipose tissue metabolism is closely linked to insulin resistance, and differential fat distributions are associated with disorders like hypertension, diabetes, and cardiovascular disease. Adipose tissues vary in their impact on metabolic risk due to diverse gene expression profiles, leading to diff...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042633/ https://www.ncbi.nlm.nih.gov/pubmed/21403826 http://dx.doi.org/10.1155/2011/490650 |
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author | Bjørndal, Bodil Burri, Lena Staalesen, Vidar Skorve, Jon Berge, Rolf K. |
author_facet | Bjørndal, Bodil Burri, Lena Staalesen, Vidar Skorve, Jon Berge, Rolf K. |
author_sort | Bjørndal, Bodil |
collection | PubMed |
description | Adipose tissue metabolism is closely linked to insulin resistance, and differential fat distributions are associated with disorders like hypertension, diabetes, and cardiovascular disease. Adipose tissues vary in their impact on metabolic risk due to diverse gene expression profiles, leading to differences in lipolysis and in the production and release of adipokines and cytokines, thereby affecting the function of other tissues. In this paper, the roles of the various adipose tissues in obesity are summarized, with particular focus on mitochondrial function. In addition, we discuss how a functionally mitochondrial-targeted compound, the modified fatty acid tetradecylthioacetic acid (TTA), can influence mitochondrial function and decrease the size of specific fat depots. |
format | Text |
id | pubmed-3042633 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-30426332011-03-14 Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents Bjørndal, Bodil Burri, Lena Staalesen, Vidar Skorve, Jon Berge, Rolf K. J Obes Review Article Adipose tissue metabolism is closely linked to insulin resistance, and differential fat distributions are associated with disorders like hypertension, diabetes, and cardiovascular disease. Adipose tissues vary in their impact on metabolic risk due to diverse gene expression profiles, leading to differences in lipolysis and in the production and release of adipokines and cytokines, thereby affecting the function of other tissues. In this paper, the roles of the various adipose tissues in obesity are summarized, with particular focus on mitochondrial function. In addition, we discuss how a functionally mitochondrial-targeted compound, the modified fatty acid tetradecylthioacetic acid (TTA), can influence mitochondrial function and decrease the size of specific fat depots. Hindawi Publishing Corporation 2011 2011-02-15 /pmc/articles/PMC3042633/ /pubmed/21403826 http://dx.doi.org/10.1155/2011/490650 Text en Copyright © 2011 Bodil Bjørndal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Bjørndal, Bodil Burri, Lena Staalesen, Vidar Skorve, Jon Berge, Rolf K. Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents |
title | Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents |
title_full | Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents |
title_fullStr | Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents |
title_full_unstemmed | Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents |
title_short | Different Adipose Depots: Their Role in the Development of Metabolic Syndrome and Mitochondrial Response to Hypolipidemic Agents |
title_sort | different adipose depots: their role in the development of metabolic syndrome and mitochondrial response to hypolipidemic agents |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042633/ https://www.ncbi.nlm.nih.gov/pubmed/21403826 http://dx.doi.org/10.1155/2011/490650 |
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