Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism

Inositol-requiring 1 (IRE1)/X-box-binding protein 1 (XBP1)-mediated signalling represents the most conserved branch of the unfolded protein response. A series of recent studies reveal novel and potentially ancient roles for this pathway in the coordination of metabolic and immune responses.

Detalles Bibliográficos
Autores principales: Kaufman, Randal J, Cao, Siyan
Formato: Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2010
Materias:
Closeup
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042734/
https://www.ncbi.nlm.nih.gov/pubmed/20533428
http://dx.doi.org/10.1002/emmm.201000076
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author Kaufman, Randal J
Cao, Siyan
author_facet Kaufman, Randal J
Cao, Siyan
author_sort Kaufman, Randal J
collection PubMed
description Inositol-requiring 1 (IRE1)/X-box-binding protein 1 (XBP1)-mediated signalling represents the most conserved branch of the unfolded protein response. A series of recent studies reveal novel and potentially ancient roles for this pathway in the coordination of metabolic and immune responses.
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spelling pubmed-30427342011-06-01 Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism Kaufman, Randal J Cao, Siyan EMBO Mol Med Closeup Inositol-requiring 1 (IRE1)/X-box-binding protein 1 (XBP1)-mediated signalling represents the most conserved branch of the unfolded protein response. A series of recent studies reveal novel and potentially ancient roles for this pathway in the coordination of metabolic and immune responses. WILEY-VCH Verlag 2010-06 /pmc/articles/PMC3042734/ /pubmed/20533428 http://dx.doi.org/10.1002/emmm.201000076 Text en Copyright © 2010 EMBO Molecular Medicine
spellingShingle Closeup
Kaufman, Randal J
Cao, Siyan
Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism
title Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism
title_full Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism
title_fullStr Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism
title_full_unstemmed Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism
title_short Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism
title_sort inositol-requiring 1/x-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism
topic Closeup
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042734/
https://www.ncbi.nlm.nih.gov/pubmed/20533428
http://dx.doi.org/10.1002/emmm.201000076
work_keys_str_mv AT kaufmanrandalj inositolrequiring1xboxbindingprotein1isaregulatoryhubthatlinksendoplasmicreticulumhomeostasiswithinnateimmunityandmetabolism
AT caosiyan inositolrequiring1xboxbindingprotein1isaregulatoryhubthatlinksendoplasmicreticulumhomeostasiswithinnateimmunityandmetabolism

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