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Caspase-3 Contributes to ZO-1 and Cl-5 Tight-Junction Disruption in Rapid Anoxic Neurovascular Unit Damage

BACKGROUND: Tight-junction (TJ) protein degradation is a decisive step in hypoxic blood-brain barrier (BBB) breakdown in stroke. In this study we elucidated the impact of acute cerebral ischemia on TJ protein arrangement and the role of the apoptotic effector protease caspase-3 in this context. METH...

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Detalles Bibliográficos
Autores principales:	Zehendner, Christoph M., Librizzi, Laura, de Curtis, Marco, Kuhlmann, Christoph R. W., Luhmann, Heiko J.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043060/ https://www.ncbi.nlm.nih.gov/pubmed/21364989 http://dx.doi.org/10.1371/journal.pone.0016760

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