Cargando…

Identifying Consensus Disease Pathways in Parkinson's Disease Using an Integrative Systems Biology Approach

Parkinson's disease (PD) has had six genome-wide association studies (GWAS) conducted as well as several gene expression studies. However, only variants in MAPT and SNCA have been consistently replicated. To improve the utility of these approaches, we applied pathway analyses integrating both G...

Descripción completa

Detalles Bibliográficos
Autores principales:	Edwards, Yvonne J. K., Beecham, Gary W., Scott, William K., Khuri, Sawsan, Bademci, Guney, Tekin, Demet, Martin, Eden R., Jiang, Zhijie, Mash, Deborah C., ffrench-Mullen, Jarlath, Pericak-Vance, Margaret A., Tsinoremas, Nicholas, Vance, Jeffery M.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043094/ https://www.ncbi.nlm.nih.gov/pubmed/21364952 http://dx.doi.org/10.1371/journal.pone.0016917

Ejemplares similares

C9ORF72 Intermediate Repeat Copies Are a Significant Risk Factor for Parkinson Disease
por: Nuytemans, Karen, et al.
Publicado: (2013)

A Rare Novel Deletion of the Tyrosine Hydroxylase Gene in Parkinson Disease
por: Bademci, Güney, et al.
Publicado: (2010)

Comparison of Three Targeted Enrichment Strategies on the SOLiD Sequencing Platform
por: Hedges, Dale J., et al.
Publicado: (2011)

Genome-wide brain DNA methylation analysis suggests epigenetic reprogramming in Parkinson disease
por: Young, Juan I., et al.
Publicado: (2019)

DNA variants in CACNA1C modify Parkinson disease risk only when vitamin D level is deficient
por: Wang, Liyong, et al.
Publicado: (2016)

Overlap between Parkinson disease and Alzheimer disease in ABCA7 functional variants
por: Nuytemans, Karen, et al.
Publicado: (2016)

GenSensor Suite: A Web-Based Tool for the Analysis of Gene and Protein Interactions, Pathways, and Regulation
por: Gosink, Mark, et al.
Publicado: (2011)

A Genomic Pathway Approach to a Complex Disease: Axon Guidance and Parkinson Disease
por: Lesnick, Timothy G, et al.
Publicado: (2007)

Gene Expression in Human Hippocampus from Cocaine Abusers Identifies Genes which Regulate Extracellular Matrix Remodeling
por: Mash, Deborah C., et al.
Publicado: (2007)

Coronary collateralization shows sex and racial-ethnic differences in obstructive artery disease patients
por: Liu, Zhi, et al.
Publicado: (2017)

Neuropathological lesions and their contribution to dementia and cognitive impairment in a heterogeneous clinical population
por: Godrich, Dana, et al.
Publicado: (2022)

Comparative analysis of genome sequences from four strains of the Buchnera aphidicola Mp endosymbion of the green peach aphid, Myzus persicae
por: Jiang, Zhijie, et al.
Publicado: (2013)

Dementia Revealed: Novel Chromosome 6 Locus for Late-Onset Alzheimer Disease Provides Genetic Evidence for Folate-Pathway Abnormalities
por: Naj, Adam C., et al.
Publicado: (2010)

Use of local genetic ancestry to assess TOMM40-523′ and risk for Alzheimer disease
por: Bussies, Parker L., et al.
Publicado: (2020)

Novel Variants in LRRK2 and GBA Identified in Latino Parkinson Disease Cohort Enriched for Caribbean Origin
por: Nuytemans, Karen, et al.
Publicado: (2020)

Exome Sequencing of Extended Families with Alzheimer’s Disease Identifies Novel Genes Implicated in Cell Immunity and Neuronal Function
por: Cukier, HN, et al.
Publicado: (2017)

Segregation of a rare TTC3 variant in an extended family with late-onset Alzheimer disease
por: Kohli, Martin A., et al.
Publicado: (2016)

The Impact of the Human Genome Project on Complex Disease
por: Cooke Bailey, Jessica N., et al.
Publicado: (2014)

GWAS analysis implicates NF-κB-mediated induction of inflammatory T cells in multiple sclerosis
por: Hussman, J P, et al.
Publicado: (2016)

Regional Differential Genetic Response of Human Articular Cartilage to Impact Injury
por: Vernon, Lauren L., et al.
Publicado: (2015)

Pesticide exposure and risk of Parkinson's disease: A family-based case-control study
por: Hancock, Dana B, et al.
Publicado: (2008)

Statistical Viewer: a tool to upload and integrate linkage and association data as plots displayed within the Ensembl genome browser
por: Stenger, Judith E, et al.
Publicado: (2005)

Pathway-PDT: a flexible pathway analysis tool for nuclear families
por: Park, Yo Son, et al.
Publicado: (2013)

ABCA7 frameshift deletion associated with Alzheimer disease in African Americans
por: Cukier, Holly N., et al.
Publicado: (2016)

Analyses of del(GJB6‐D13S1830) and del(GJB6‐D13S1834) deletions in a large cohort with hearing loss: Caveats to interpretation of molecular test results in multiplex families
por: Pandya, Arti, et al.
Publicado: (2020)

FE65 Binds Teashirt, Inhibiting Expression of the Primate-Specific Caspase-4
por: Kajiwara, Yuji, et al.
Publicado: (2009)

The Puerto Rico Alzheimer Disease Initiative (PRADI): A Multisource Ascertainment Approach
por: Feliciano-Astacio, Briseida E., et al.
Publicado: (2019)

MicroRNA signature of the human developing pancreas
por: Rosero, Samuel, et al.
Publicado: (2010)

Comprehensive Analysis of Deafness Genes in Families with Autosomal Recessive Nonsyndromic Hearing Loss
por: Atik, Tahir, et al.
Publicado: (2015)

Genome sequencing reveals novel noncoding variants in PLA2G6 and LMNB1 causing progressive neurologic disease
por: Borja, Nicholas, et al.
Publicado: (2022)

Combinatorial Mismatch Scan (CMS) for loci associated with dementia in the Amish
por: McCauley, Jacob L, et al.
Publicado: (2006)

SRRM2, a Potential Blood Biomarker Revealing High Alternative Splicing in Parkinson's Disease
por: Shehadeh, Lina A., et al.
Publicado: (2010)

Motivations for Participation in Parkinson Disease Genetic Research Among Hispanics versus Non-Hispanics
por: Nuytemans, Karen, et al.
Publicado: (2019)

UTILITY OF BLOOD PRESSURE GENETIC RISK SCORE IN ADMIXED HISPANIC SAMPLES
por: Beecham, Ashley H., et al.
Publicado: (2016)

A noise-reduction GWAS analysis implicates altered regulation of neurite outgrowth and guidance in autism
por: Hussman, John P, et al.
Publicado: (2011)

Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations
por: Rajabli, Farid, et al.
Publicado: (2018)

Dominant deafness–onychodystrophy syndrome caused by an ATP6V1B2 mutation
por: Menendez, Ibis, et al.
Publicado: (2017)

Novel GPR156 variants confirm its role in moderate sensorineural hearing loss
por: Ramzan, Memoona, et al.
Publicado: (2023)

Identification of TMEM230 mutations in familial Parkinson’s disease
por: Deng, Han-Xiang, et al.
Publicado: (2016)

Examination of Candidate Exonic Variants for Association to Alzheimer Disease in the Amish
por: D’Aoust, Laura N., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_p0l4lpn4dcbul13gsb91n28qaq