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Marginal increase of sunitinib exposure by grapefruit juice

PURPOSE: The drug label of sunitinib includes a warning for concomitant use of grapefruit juice (GJ) but clinical evidence for this drug interaction is lacking. The aim of this study is to determine the effect of GJ, a potent intestinal cytochrome P450 (CYP) 3A4 inhibitor, on steady-state sunitinib...

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Detalles Bibliográficos
Autores principales:	van Erp, Nielka P., Baker, Sharyn D., Zandvliet, Anthe S., Ploeger, Bart A., den Hollander, Margaret, Chen, Zhaoyuan, den Hartigh, Jan, König-Quartel, Jacqueline M. C., Guchelaar, Henk-Jan, Gelderblom, Hans
Formato:	Texto
Lenguaje:	English
Publicado:	Springer-Verlag 2010
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043256/ https://www.ncbi.nlm.nih.gov/pubmed/20512335 http://dx.doi.org/10.1007/s00280-010-1367-0

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