Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy

Glomerular thrombotic microangiopathy is a hallmark feature of haemolytic uraemic syndrome, the leading cause of acute renal failure in childhood. This paper is a review of the different mechanistic pathways that lead to this histological picture in the kidney. It will focus on atypical HUS and comp...

Descripción completa

Detalles Bibliográficos
Autores principales: Keir, Lindsay, Coward, Richard J. M.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2010
Materias:
Educational Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043262/
https://www.ncbi.nlm.nih.gov/pubmed/20949284
http://dx.doi.org/10.1007/s00467-010-1637-4
_version_ 1782198616540053504
author Keir, Lindsay
Coward, Richard J. M.
author_facet Keir, Lindsay
Coward, Richard J. M.
author_sort Keir, Lindsay
collection PubMed
description Glomerular thrombotic microangiopathy is a hallmark feature of haemolytic uraemic syndrome, the leading cause of acute renal failure in childhood. This paper is a review of the different mechanistic pathways that lead to this histological picture in the kidney. It will focus on atypical HUS and complement dysregulation, but will also highlight some other recent advances in our understanding of this condition, including the potential role of the molecule vascular endothelial growth factor- A (VEGF-A).
format Text
id pubmed-3043262
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher Springer-Verlag
record_format MEDLINE/PubMed
spelling pubmed-30432622011-04-04 Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy Keir, Lindsay Coward, Richard J. M. Pediatr Nephrol Educational Review Glomerular thrombotic microangiopathy is a hallmark feature of haemolytic uraemic syndrome, the leading cause of acute renal failure in childhood. This paper is a review of the different mechanistic pathways that lead to this histological picture in the kidney. It will focus on atypical HUS and complement dysregulation, but will also highlight some other recent advances in our understanding of this condition, including the potential role of the molecule vascular endothelial growth factor- A (VEGF-A). Springer-Verlag 2010-10-15 2011-04 /pmc/articles/PMC3043262/ /pubmed/20949284 http://dx.doi.org/10.1007/s00467-010-1637-4 Text en © IPNA 2010
spellingShingle Educational Review
Keir, Lindsay
Coward, Richard J. M.
Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy
title Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy
title_full Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy
title_fullStr Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy
title_full_unstemmed Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy
title_short Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy
title_sort advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy
topic Educational Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3043262/
https://www.ncbi.nlm.nih.gov/pubmed/20949284
http://dx.doi.org/10.1007/s00467-010-1637-4
work_keys_str_mv AT keirlindsay advancesinourunderstandingofthepathogenesisofglomerularthromboticmicroangiopathy
AT cowardrichardjm advancesinourunderstandingofthepathogenesisofglomerularthromboticmicroangiopathy

Ejemplares similares